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miR-33A Endonucleolytic RISC [cytosol]
Stable Identifier
R-HSA-9624920
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
miR-33A:AGO2:MOV10:TNRC6
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Homo sapiens)
ABCA1 mRNA is translated (Homo sapiens)
ABCA1 mRNA:miR-33 RISC [cytosol] (Homo sapiens)
miR-33 RISC [cytosol] (Homo sapiens)
miR-33A RISC [cytosol] (Homo sapiens)
miR-33A Endonucleolytic RISC [cytosol] (Homo sapiens)
miR-33 RISC [cytosol] (Homo sapiens)
miR-33A RISC [cytosol] (Homo sapiens)
miR-33A Endonucleolytic RISC [cytosol] (Homo sapiens)
miR-33 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)
ABCA1 mRNA:miR-33 RISC [cytosol] (Homo sapiens)
miR-33 RISC [cytosol] (Homo sapiens)
miR-33A RISC [cytosol] (Homo sapiens)
miR-33A Endonucleolytic RISC [cytosol] (Homo sapiens)
miR-33 RISC [cytosol] (Homo sapiens)
miR-33A RISC [cytosol] (Homo sapiens)
miR-33A Endonucleolytic RISC [cytosol] (Homo sapiens)
General
The RNA-induced silencing complex contains an Argonaute (AGO) protein, whose PAZ domain binds the 3' end of the miRNA. The PIWI domain of AGO is responsible for cleavage of target RNAs, that is, RNAs complementary to the miRNA. Only AGO2 (EIF2C2) is capable of cleavage, however. AGO1 (EIF2C1), AGO3 (EIF2C3), and AGO4 (EIF2C4) repress translation of target RNAs by binding without cleavage. In vivo, cleavage by AGO2 and repression of translation by all AGOs require interaction with a TNRC6 protein (GW182 protein) and MOV10. The interaction with TNRC6 proteins is also responsible for localizing the AGO complex to Processing Bodies (P-bodies). Tethering of the C-terminal domain of a TNRC6 protein to a mRNA is sufficient to cause repression of translation.
Participants
components
miR-33A:AGO2 [cytosol]
(Homo sapiens)
MOV10 [cytosol]
(Homo sapiens)
TNRC6 (GW182) [cytosol]
(Homo sapiens)
Participates
as a member of
miR-33A RISC [cytosol] (Homo sapiens)
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