Reactome | pro-SFTPB translocates from ER membrane to multivesicle body

pro-SFTPB translocates from ER membrane to multivesicle body

Stable Identifier

R-HSA-9624789

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, multivesicular body lumen

ReviewStatus

5/5

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pro-SFTPB translocates from ER membrane to multivesicle body

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Surfactant proteins (SFTPs) are trafficked from the ER membrane to lamellar bodies (LBs) via the multi-vesicle body (MVB). The pro-SFTPs B and C are cleaved here to produce functional SFTPs (Voorhout et al. 1992, Weaver et al. 1992).

Literature References

PubMed ID	Title	Journal	Year
1636732	Processing of surfactant protein B proprotein by a cathepsin D-like protease Weaver, TE, Lin, S, Bogucki, B, Dey, C	Am. J. Physiol.	1992
1415726	Intracellular processing of pulmonary surfactant protein B in an endosomal/lysosomal compartment Voorhout, WF, Veenendaal, T, Haagsman, HP, Weaver, TE, Whitsett, JA, van Golde, LM, Geuze, HJ	Am. J. Physiol.	1992