Reactome | SFTPD 12mer translocates from ER membrane to extracellular region

SFTPD 12mer translocates from ER membrane to extracellular region

Stable Identifier

R-HSA-9624778

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, extracellular region

ReviewStatus

5/5

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SFTPD 12mer translocates from ER membrane to extracellular region

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The pulmonary collectins, surfactant proteins A1, A2, A3 and D (SFTPAs, SFTPD 12mer), play important roles in innate host defense by binding and clearing invading microbes from the lung. They also influence surfactant homeostasis, contributing to the physical structures of lipids in the alveoli and to the regulation of surfactant function and metabolism. They are directly secreted from alveolar type II cells into the airway to function as part of the surfactant. The mechanism of secretion is unknown (Andreeva et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17496061	Regulation of surfactant secretion in alveolar type II cells Voyno-Yasenetskaya, TA, Kutuzov, MA, Andreeva, AV	Am. J. Physiol. Lung Cell Mol. Physiol.	2007