Reactome | CEBPA binds CDKN1A (p21)

CEBPA binds CDKN1A (p21)

Stable Identifier

R-HSA-9624668

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CEBPA interacts with CDKN1A (p21), resulting in a cooperative inhibition of CDK2 and cellular proliferation (Harris et al. 2001). CEBPA also increases the cellular abundance of CDKN1A by stabilizing the CDKN1A protein and activating transcription of the CDKN1A gene (Timchenko et al. 1996, Quintana-Bustamante et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
11369759	CCAAT/enhancer-binding protein-alpha cooperates with p21 to inhibit cyclin-dependent kinase-2 activity and induces growth arrest independent of DNA binding Harris, TE, Albrecht, JH, Nakanishi, M, Darlington, GJ	J. Biol. Chem.	2001
8846917	CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein Timchenko, NA, Wilde, M, Nakanishi, M, Smith, JR, Darlington, GJ	Genes Dev.	1996
22371011	Overexpression of wild-type or mutants forms of CEBPA alter normal human hematopoiesis Quintana-Bustamante, O, Lan-Lan Smith, S, Griessinger, E, Reyal, Y, Vargaftig, J, Lister, TA, Fitzgibbon, J, Bonnet, D	Leukemia	2012