CEBPA binds CDKN1A (p21)

Stable Identifier
Reaction [binding]
Homo sapiens
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CEBPA interacts with CDKN1A (p21), resulting in a cooperative inhibition of CDK2 and cellular proliferation (Harris et al. 2001). CEBPA also increases the cellular abundance of CDKN1A by stabilizing the CDKN1A protein and activating transcription of the CDKN1A gene (Timchenko et al. 1996, Quintana-Bustamante et al. 2012).

Literature References
PubMed ID Title Journal Year
11369759 CCAAT/enhancer-binding protein-alpha cooperates with p21 to inhibit cyclin-dependent kinase-2 activity and induces growth arrest independent of DNA binding

Nakanishi, M, Albrecht, JH, Harris, TE, Darlington, GJ

J. Biol. Chem. 2001
8846917 CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein

Nakanishi, M, Wilde, M, Smith, JR, Timchenko, NA, Darlington, GJ

Genes Dev. 1996
22371011 Overexpression of wild-type or mutants forms of CEBPA alter normal human hematopoiesis

Lan-Lan Smith, S, Quintana-Bustamante, O, Vargaftig, J, Lister, TA, Bonnet, D, Fitzgibbon, J, Reyal, Y, Griessinger, E

Leukemia 2012
Orthologous Events
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