MMPs cleave HB-EGF

Stable Identifier
R-HSA-9624272
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Estrogen-stimulation of ESR1 activates downstream signaling pathways that results in the release of HB-EGF in an IGF- MMP- and EGFR-dependent manner (Razandi et al, 2003; Song et al, 2004; Song et al, 2007; Santen et al, 2009). Based on studies in other systems, candidate MMPs for the cleavage of HB-EGF include MMP2, MMP3, MMP7 and MMP9 (Suzuki et al, 1997; Yu et al, 2002; Razandi et al, 2003). Although direct cleavage of HB-EGF by MMPs downstream of estrogen signaling has not been demonstrated, estrogen-stimulated signaling through EGFR is abrogated after treatment of cells with an HB-EGF neutralizing antibody (Razandi et al, 2003; Song et al, 2007).

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Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of MMP2,3,7,9 [extracellular region]
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Activity
This event is regulated
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