IGFBP1 gene expression is stimulated by FOXO1,FOXO3,FOXO4

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R-HSA-9623427
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Reaction [omitted]
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Homo sapiens
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FOXO1 (Tang et al. 1999), FOXO3 (Hall et al. 2000) and FOXO4 (Kops et al. 1999, Yang et al. 2002) directly stimulate transcription of IGFBP1 gene, encoding Insulin-like growth factor-binding protein 1.

Literature References
PubMed ID Title Journal Year
10913147 Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins

Hall, RK, Yamasaki, T, Kucera, T, Waltner-Law, M, O'Brien, R, Granner, DK

J. Biol. Chem. 2000
10217147 Direct control of the Forkhead transcription factor AFX by protein kinase B

Kops, GJ, de Ruiter, ND, De Vries-Smits, AM, Powell, DR, Bos, JL, Burgering, BM

Nature 1999
11779849 An mRNA splice variant of the AFX gene with altered transcriptional activity

Yang, Z, Whelan, J, Babb, R, Bowen, BR

J. Biol. Chem. 2002
10358014 Negative regulation of the forkhead transcription factor FKHR by Akt

Tang, ED, Núñez, G, Barr, FG, Guan, KL

J. Biol. Chem. 1999
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