IGFBP1 gene expression is stimulated by FOXO1,FOXO3,FOXO4

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Reaction [omitted]
Homo sapiens
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FOXO1 (Tang et al. 1999), FOXO3 (Hall et al. 2000) and FOXO4 (Kops et al. 1999, Yang et al. 2002) directly stimulate transcription of IGFBP1 gene, encoding Insulin-like growth factor-binding protein 1.

Literature References
PubMed ID Title Journal Year
10217147 Direct control of the Forkhead transcription factor AFX by protein kinase B

Powell, DR, Burgering, BM, De Vries-Smits, AM, de Ruiter, ND, Bos, JL, Kops, GJ

Nature 1999
10913147 Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins

Waltner-Law, M, Kucera, T, Granner, DK, Hall, RK, Yamasaki, T, O'Brien, R

J. Biol. Chem. 2000
11779849 An mRNA splice variant of the AFX gene with altered transcriptional activity

Bowen, BR, Whelan, J, Babb, R, Yang, Z

J. Biol. Chem. 2002
10358014 Negative regulation of the forkhead transcription factor FKHR by Akt

Guan, KL, Barr, FG, Núñez, G, Tang, ED

J. Biol. Chem. 1999
This event is regulated
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