IGFBP1 gene expression is stimulated by FOXO1,FOXO3,FOXO4

Stable Identifier
R-HSA-9623427
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IGFBP1 gene expression is stimulated by FOXO1,FOXO3,FOXO4
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
FOXO1 (Tang et al. 1999), FOXO3 (Hall et al. 2000) and FOXO4 (Kops et al. 1999, Yang et al. 2002) directly stimulate transcription of IGFBP1 gene, encoding Insulin-like growth factor-binding protein 1.
Literature References
PubMed ID Title Journal Year
10217147 Direct control of the Forkhead transcription factor AFX by protein kinase B

Kops, GJ, de Ruiter, ND, De Vries-Smits, AM, Powell, DR, Bos, JL, Burgering, BM

Nature 1999
10913147 Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins

Hall, RK, Yamasaki, T, Kucera, T, Waltner-Law, M, O'Brien, R, Granner, DK

J. Biol. Chem. 2000
11779849 An mRNA splice variant of the AFX gene with altered transcriptional activity

Yang, Z, Whelan, J, Babb, R, Bowen, BR

J. Biol. Chem. 2002
10358014 Negative regulation of the forkhead transcription factor FKHR by Akt

Tang, ED, Núñez, G, Barr, FG, Guan, KL

J. Biol. Chem. 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FOXO1,FOXO3,FOXO4:IGFBP1 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO3,FOXO4 [nucleoplasm]
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Donlon, T  (2018-10-17)
Bertaggia, E  (2018-10-26)
Created
Orlic-Milacic, M  (2018-10-04)
Cite Us!