FOXO1,FOXO3,FOXO4 bind IGFBP1 gene promoter

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
FOXO1 (Tang et al. 1999), FOXO3 (Brunet et al. 1999, Hall et al. 2000) and FOXO4 (Kops et al. 1999, Yang et al. 2002) bind insulin response elements in the promoter of the IGFBP1 gene, encoding Insulin-like growth factor-binding protein 1. FOXO-mediated regulation of IGFBP1 gene expression is negatively regulated by insulin.
Literature References
PubMed ID Title Journal Year
10217147 Direct control of the Forkhead transcription factor AFX by protein kinase B

Powell, DR, Burgering, BM, De Vries-Smits, AM, de Ruiter, ND, Bos, JL, Kops, GJ

Nature 1999
10102273 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Hu, LS, Bonni, A, Brunet, A, Blenis, J, Zigmond, MJ, Anderson, MJ, Lin, MZ, Greenberg, ME, Juo, P, Arden, KC

Cell 1999
10913147 Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins

Waltner-Law, M, Kucera, T, Granner, DK, Hall, RK, Yamasaki, T, O'Brien, R

J. Biol. Chem. 2000
11779849 An mRNA splice variant of the AFX gene with altered transcriptional activity

Bowen, BR, Whelan, J, Babb, R, Yang, Z

J. Biol. Chem. 2002
10358014 Negative regulation of the forkhead transcription factor FKHR by Akt

Guan, KL, Barr, FG, Núñez, G, Tang, ED

J. Biol. Chem. 1999
This event is regulated
Cite Us!