Reactome | G6PC gene expression is stimulated by FOXO1,FOXO3,FOXO4,FOXO6

G6PC gene expression is stimulated by FOXO1,FOXO3,FOXO4,FOXO6

Stable Identifier

R-HSA-9623192

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

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G6PC gene expression is stimulated by FOXO1,FOXO3,FOXO4,FOXO6

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FOXO1 (Onuma et al. 2006), which can function in collaboration with PPARGC1A (PGC-1alpha) (Puigserver et al. 2003), FOXO3 (Onuma et al. 2006), FOXO4 (Yang et al. 2002) and FOXO6 (Kim et al. 2011) directly stimulate transcription of the G6PC gene, encoding Glucose-6-phosphatase. G6PC generates glucose and enables maintenance of steady glucose blood levels during fasting. FOXO6 mRNA levels increase in liver cells during fasting (Kim et al. 2011). Upregulation of G6PC expression by FOXO1 and FOXO6 is inhibited by insulin. FOXO-mediated induction of G6PC is involved in excessive endogenous glucose production and fasting hyperglycemia in diabetes (Kim et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
16840535	Correlation between FOXO1a (FKHR) and FOXO3a (FKHRL1) binding and the inhibition of basal glucose-6-phosphatase catalytic subunit gene transcription by insulin Onuma, H, Vander Kooi, BT, Boustead, JN, Oeser, JK, O'Brien, RM	Mol. Endocrinol.	2006
11779849	An mRNA splice variant of the AFX gene with altered transcriptional activity Yang, Z, Whelan, J, Babb, R, Bowen, BR	J. Biol. Chem.	2002