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POMC gene expression is inhibited by FOXO1
Stable Identifier
R-HSA-9623072
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
POMC gene expression is inhibited by FOXO1 (Homo sapiens)
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Based on studies in mice, FOXO1 represses transcription of the POMC gene, encoding Pro-opiomelanocortin, in hypothalamic anorexigenic neurons. FOXO1-mediated repression of the POMC gene involves the recruitment of histone deacetylases and the NcoR repressor complex to the POMC gene promoter. Leptin inhibits binding of FOXO1 and promotes binding of STAT3 to the POMC gene promoter, thus stimulating POMC gene transcription. One of the cleavage products of Pro-opiomelanocortin is melanocyte-stimulating hormone alpha, which suppresses food intake (Kitamura et al. 2006, Kim et al. 2006).
Participants
Input
POMC gene [nucleoplasm]
(Homo sapiens)
Output
POMC(138-150) [extracellular region]
(Homo sapiens)
Participates
as an event of
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
This event is regulated
Negatively by
Regulator
FOXO1:POMC gene [nucleoplasm]
(Homo sapiens)
Active Unit
FOXO1 [nucleoplasm]
Inferred From
Pomc gene expression is inhibited by Foxo1 (Mus musculus)
Authored
Orlic-Milacic, M (2018-10-11)
Reviewed
Bertaggia, E (2018-10-26)
Donlon, T (2018-10-17)
Created
Orlic-Milacic, M (2018-10-02)
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