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FOXO1 binds POMC gene promoter
Stable Identifier
R-HSA-9623059
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
FOXO1 binds POMC gene promoter (Homo sapiens)
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Based on studies in mice, FOXO1 binds the promoter of the POMC gene, encoding Pro-opiomelanocortin (Kitamura et al. 2006). FOXO1-mediated repression of the POMC gene is positively regulated by SIRT1-mediated deacetylation of FOXO1 (Cakir et al. 2009).
Participants
Input
FOXO1 [nucleoplasm]
(Homo sapiens)
POMC gene [nucleoplasm]
(Homo sapiens)
Output
FOXO1:POMC gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
Inferred From
Foxo1 binds Pomc gene promoter (Mus musculus)
Authored
Orlic-Milacic, M (2018-10-11)
Reviewed
Bertaggia, E (2018-10-26)
Donlon, T (2018-10-17)
Created
Orlic-Milacic, M (2018-10-02)
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