AGRP gene expression is stimulated by FOXO1

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R-HSA-9623023
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Reaction [omitted]
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Homo sapiens
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Based on studies in mice, FOXO1 directly promotes transcription of the AGRP gene, encoding Agouti-related protein, in orexigenic neurons of the hypothalamus. AGRP promotes food intake and weight gain. FOXO1-mediated upregulation of AGRP gene transcription involves recruitment of histone actyltransferases to the AGRP gene promoter and displacement of the NcoR transcriptional repressor complex. Leptin inhibits FOXO1-mediated upregulation of AGRP, probably acting through STAT3 (Kitamura et al. 2006, Kim et al. 2006).

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