AGRP gene expression is stimulated by FOXO1

Stable Identifier
R-HSA-9623023
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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AGRP gene expression is stimulated by FOXO1
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Based on studies in mice, FOXO1 directly promotes transcription of the AGRP gene, encoding Agouti-related protein, in orexigenic neurons of the hypothalamus. AGRP promotes food intake and weight gain. FOXO1-mediated upregulation of AGRP gene transcription involves recruitment of histone actyltransferases to the AGRP gene promoter and displacement of the NcoR transcriptional repressor complex. Leptin inhibits FOXO1-mediated upregulation of AGRP, probably acting through STAT3 (Kitamura et al. 2006, Kim et al. 2006).
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FOXO1:AGRP gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO1 [nucleoplasm]
Inferred From
Agrp gene expression is stimulated by Foxo1 (Mus musculus)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-10-02)
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