Based on studies in mice, FOXO1 directly promotes transcription of the AGRP gene, encoding Agouti-related protein, in orexigenic neurons of the hypothalamus. AGRP promotes food intake and weight gain. FOXO1-mediated upregulation of AGRP gene transcription involves recruitment of histone actyltransferases to the AGRP gene promoter and displacement of the NcoR transcriptional repressor complex. Leptin inhibits FOXO1-mediated upregulation of AGRP, probably acting through STAT3 (Kitamura et al. 2006, Kim et al. 2006).