Substrate:LAMP2a binds HSP90

Stable Identifier
R-HSA-9622831
Type
Reaction [binding]
Species
Homo sapiens
Compartment
lysosomal lumen, lysosomal membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Substrate:LAMP2a binds HSP90
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Heat shock cognate 71 kDa protein (HSPA8) translocates substrates from cytosol to lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a). HSPA8 is then released from this complex. Subsequently, Heat shock protein HSP 90 binds to the lysosomal luminal end of LAMP2a (Bandyopadhyay U et al. 2008). This facilitates the multimerization of LAMP2a and internalization of substrate into the lumen. Experiments confirming this binding were performed on rat models.

Literature References
PubMed ID Title Journal Year
29626215 The coming of age of chaperone-mediated autophagy

Kaushik, S, Cuervo, AM

Nat. Rev. Mol. Cell Biol. 2018
18644871 The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane

Bandyopadhyay, U, Kaushik, S, Varticovski, L, Cuervo, AM

Mol. Cell. Biol. 2008
Participants
Input
Output
Participates
as an event of
Inferred From
Substrate:Lamp2a binds Hsp90 (Rattus norvegicus)
Authored
Varusai, TM  (2019-02-21)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2018-10-02)
Cite Us!