Substrate:LAMP2a binds HSP90

Stable Identifier
R-HSA-9622831
Type
Reaction
Species
Homo sapiens
Compartment
lysosomal lumen, lysosomal membrane
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Substrate:LAMP2a binds HSP90
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Heat shock cognate 71 kDa protein (HSPA8) translocates substrates from cytosol to lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a). HSPA8 is then released from this complex. Subsequently, Heat shock protein HSP 90 binds to the lysosomal luminal end of LAMP2a (Bandyopadhyay U et al. 2008). This facilitates the multimerization of LAMP2a and internalization of substrate into the lumen. Experiments confirming this binding were performed on rat models.

Literature References
PubMed ID Title Journal Year
18644871 The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane

Cuervo, AM, Kaushik, S, Bandyopadhyay, U, Varticovski, L

Mol. Cell. Biol. 2008
29626215 The coming of age of chaperone-mediated autophagy

Cuervo, AM, Kaushik, S

Nat. Rev. Mol. Cell Biol. 2018
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Substrate:Lamp2a binds Hsp90 (Rattus norvegicus)
Authored
Varusai, TM  (2019-02-21)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2018-10-02)
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