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Substrate:LAMP2a binds HSP90
Stable Identifier
R-HSA-9622831
Type
Reaction [binding]
Species
Homo sapiens
Compartment
lysosomal lumen
,
lysosomal membrane
ReviewStatus
5/5
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Autophagy (Homo sapiens)
Chaperone Mediated Autophagy (Homo sapiens)
Substrate:LAMP2a binds HSP90 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Heat shock cognate 71 kDa protein (HSPA8) translocates substrates from cytosol to lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a). HSPA8 is then released from this complex. Subsequently, Heat shock protein HSP 90 binds to the lysosomal luminal end of LAMP2a (Bandyopadhyay U et al. 2008). This facilitates the multimerization of LAMP2a and internalization of substrate into the lumen. Experiments confirming this binding were performed on rat models.
Literature References
PubMed ID
Title
Journal
Year
18644871
The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane
Cuervo, AM
,
Kaushik, S
,
Bandyopadhyay, U
,
Varticovski, L
Mol. Cell. Biol.
2008
29626215
The coming of age of chaperone-mediated autophagy
Cuervo, AM
,
Kaushik, S
Nat. Rev. Mol. Cell Biol.
2018
Participants
Input
HSP90AA1, HSP90AB1 [lysosomal lumen]
(Homo sapiens)
Substrate:LAMP2a [lysosomal membrane]
(Homo sapiens)
Output
Substrate:LAMP2a:HSP90 [lysosomal membrane]
(Homo sapiens)
Participates
as an event of
Chaperone Mediated Autophagy (Homo sapiens)
Inferred From
Substrate:Lamp2a binds Hsp90 (Rattus norvegicus)
Authored
Varusai, TM (2019-02-21)
Reviewed
Metzakopian, E (2019-02-22)
Created
Varusai, TM (2018-10-02)
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