FOXO3,(FOXO1) bind BBC3 gene first intron

Stable Identifier
R-HSA-9622668
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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FOXO3 binds forkhead box elements in the first intron of the BBC3 (PUMA) gene (Dudgeon et al. 2010, Fitzwalter et al. 2018). As FOXO1 upregulates BBC3 transcription, it is probable that FOXO1 can also associate with forkhead box elements in the BBC3 gene locus.

Literature References
PubMed ID Title Journal Year
29533771 Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover

Fitzwalter, BE, Towers, CG, Sullivan, KD, Andrysik, Z, Hoh, M, Ludwig, M, O'Prey, J, Ryan, KM, Espinosa, JM, Morgan, MJ, Thorburn, A

Dev. Cell 2018
20978166 PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01

Dudgeon, C, Wang, P, Sun, X, Peng, R, Sun, Q, Yu, J, Zhang, L

Mol. Cancer Ther. 2010
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