FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter

Stable Identifier
R-HSA-9622579
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Based on studies in rat neurons, in the absence of PI3K/AKT signaling, as happens under conditions of NGF withdrawal, for example, FOXO transcription factors, FOXO3, FOXO1 and probably also FOXO4 bind evolutionarily conserved forkhead box elements in the promoter of the BCL2L11 (BIM) gene (Gilley et al. 2003) and co-immunoprecipitate with the BCL2L11 promoter-bound NF-Y complex (Hughes et al. 2011).

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