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NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter
Stable Identifier
R-HSA-9622572
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell death genes (Homo sapiens)
NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter (Homo sapiens)
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Based on studies in rat neurons, the NF-Y transcription factor complex (composed of NFYA, NFYB and NFYC) and histone acetyltransferases EP300 (p300) and/or CREBBP (CBP) constitutively bind to evolutionarily conserved sites in the promoter of the BCL2L11 (BIM) gene (Hughes et al. 2011).
Participants
Input
BCL2L11 gene [nucleoplasm]
(Homo sapiens)
CREBBP,EP300 [nucleoplasm]
(Homo sapiens)
NF-Y [nucleoplasm]
(Homo sapiens)
Output
NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
FOXO-mediated transcription of cell death genes (Homo sapiens)
Inferred From
rNF-Y and Crebbp/Ep300 constitutively bind Bim gene promoter (Rattus norvegicus)
Authored
Orlic-Milacic, M (2018-10-11)
Reviewed
Bertaggia, E (2018-10-26)
Donlon, T (2018-10-17)
Created
Orlic-Milacic, M (2018-10-01)
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