LEF1 binds the promoter of the CEBPA gene

Stable Identifier
R-HSA-9622386
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

LEF1 binds the CEBPA promoter between 559 bp and 538 bp upstream of the transcription start and directly regulates transcription of CEBPA (Skokowa et al. 2006). LEF1 is most highly expressed in promyelocytes and a reduction of LEF1 expression is associated with neutropenia.
Elevated STAT5A protein binds LEF1, inducing LEF1 degradation and inhibiting LEF1 auto-regulation and activation of LEF1 target genes, MYC, CCND1 (cyclin D1), (BIRC5) Survivin and CEBPA (Gupta et al. 2014 ).
RUNX1 and LEF1 regulate ELANE (ELA2) mRNA expression in myeloid cells by binding to its promoter (Li et al. 2003).

Literature References
PubMed ID Title Journal Year
17063141 LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia

Skokowa, J, Cario, G, Uenalan, M, Schambach, A, Germeshausen, M, Battmer, K, Zeidler, C, Lehmann, U, Eder, M, Baum, C, Grosschedl, R, Stanulla, M, Scherr, M, Welte, K

Nat. Med. 2006
Participants
Participant Of
Authored
Reviewed
Created
Cite Us!