CEBPA mRNA is translated to yield CEBPA protein

Stable Identifier
R-HSA-9622367
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In the cytosol, 80S ribosomes translate the CEBPA mRNA to yield CEBPA protein (Pabst et al. 2001, Timchenko et al. 2002, Haefliger et al. 2011). Depending on which initiation codon is used, the CEBPA mRNA can be translated to yield a 35.9 kDa protein (p42) or a 25.5 kDa protein (p30). CEBPA protein is then imported into the nucleus. The p30 isoform is not antimitotic (inferred from mouse homologs).

Literature References
PubMed ID Title Journal Year
11242107 Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

Pabst, T, Mueller, BU, Zhang, P, Radomska, HS, Narravula, S, Schnittger, S, Behre, G, Hiddemann, W, Tenen, DG

Nat. Genet. 2001
12242300 Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins

Timchenko, LT, Iakova, P, Welm, AL, Cai, ZJ, Timchenko, NA

Mol. Cell. Biol. 2002
21471526 Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML

Haefliger, S, Klebig, C, Schaubitzer, K, Schardt, J, Timchenko, N, Mueller, BU, Pabst, T

Blood 2011
Participants
Participant Of
Inferred From
Authored
Reviewed
Created
Cite Us!