Reactome | CEBPA mRNA is translated to yield CEBPA protein

CEBPA mRNA is translated to yield CEBPA protein

Stable Identifier

R-HSA-9622367

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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CEBPA mRNA is translated to yield CEBPA protein

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In the cytosol, 80S ribosomes translate the CEBPA mRNA to yield CEBPA protein (Pabst et al. 2001, Timchenko et al. 2002, Haefliger et al. 2011). Depending on which initiation codon is used, the CEBPA mRNA can be translated to yield a 35.9 kDa protein (p42) or a 25.5 kDa protein (p30). CEBPA protein is then imported into the nucleus. The p30 isoform is not antimitotic (inferred from mouse homologs).

Literature References

PubMed ID	Title	Journal	Year
12242300	Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins Timchenko, LT, Cai, ZJ, Timchenko, NA, Iakova, P, Welm, AL	Mol. Cell. Biol.	2002
11242107	Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia Zhang, P, Behre, G, Narravula, S, Schnittger, S, Mueller, BU, Tenen, DG, Hiddemann, W, Radomska, HS, Pabst, T	Nat. Genet.	2001
21471526	Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML Haefliger, S, Schaubitzer, K, Klebig, C, Schardt, J, Mueller, BU, Pabst, T, Timchenko, N	Blood	2011