EGR2 and SREBF2(1-484) dimer bind HMGCR gene

Stable Identifier
Reaction [binding]
Homo sapiens
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HMG coenzyme A reductase catalyzes a rate-limiting step in cholesterol biosynthesis and is expressed in a SREBF2- and EGR2-dependent manner during Schwann cell myelination. Cognate binding sites for both SREBF2 and EGR2 have been identified in the promoter of HMGCR, and the transcription factors act synergistically to promote transcription (Pai et al, 1998; Nagarajan et al, 2001; Verheijen et al, 2003; LeBlanc et al, 2005; Jang et al, 2010).

Literature References
PubMed ID Title Journal Year
21044070 Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes

Nagarajan, R, Keles, S, Jones, EA, Sun, G, Chang, LW, Svaren, J, Jang, SW, Srinivasan, R, Krueger, C

J. Neurochem. 2010
15836632 Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination

Wrabetz, L, Gillian-Daniel, AL, Mager, GM, Ferri, C, Svaren, J, Leblanc, SE, Srinivasan, R

J. Neurochem. 2005
14522948 Local regulation of fat metabolism in peripheral nerves

Verheijen, MH, Chrast, R, Burrola, P, Lemke, G

Genes Dev. 2003
11394999 EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression

Milbrandt, J, Watson, M, Le, N, Svaren, J, Nagarajan, R, Araki, T

Neuron 2001
9748295 Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins

Brown, MS, Pai, JT, Guryev, O, Goldstein, JL

J Biol Chem 1998
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