EGR2 and SREBF2 dimer bind CYP51A1 gene

Stable Identifier
R-HSA-9621406
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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CYP51A1 encodes lanosterol 14 alpha-demethylase, a protein involved in steroid biosynthetic pathways (Stromstedt et al, 1996; Strushkevich et al, 2010). Consistent with its expression during Schwann cell myelination, expression is synergistically activated by EGR2 and SREBF2 acting through cognate sites in the promoter (Nagarajan et al, 2001; Halder et al, 2002; LeBlanc et al, 2005; Jang et al, 2010).

Literature References
PubMed ID Title Journal Year
15836632 Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination

Leblanc, SE, Srinivasan, R, Ferri, C, Mager, GM, Gillian-Daniel, AL, Wrabetz, L, Svaren, J

J. Neurochem. 2005
21044070 Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes

Jang, SW, Srinivasan, R, Jones, EA, Sun, G, Keles, S, Krueger, C, Chang, LW, Nagarajan, R, Svaren, J

J. Neurochem. 2010
20149798 Structural basis of human CYP51 inhibition by antifungal azoles

Strushkevich, N, Usanov, SA, Park, HW

J. Mol. Biol. 2010
11394999 EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression

Nagarajan, R, Svaren, J, Le, N, Araki, T, Watson, M, Milbrandt, J

Neuron 2001
8619637 The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols

Stromstedt, M, Rozman, D, Waterman, MR

Arch Biochem Biophys 1996
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