CYP51A1 gene expression

Stable Identifier
R-HSA-9621404
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, endoplasmic reticulum membrane
ReviewStatus
5/5
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CYP51A1 gene expression
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CYP51A1 encodes lanosterol 14 alpha-demethylase, an enzyme involved in steroid biosynthesis (Stroemstedt et al, 1996; Strushkevich et al, 2010). CYP51A1 is upregulated during Schwann cell myelination in an EGR2- and SREBF2-dependent manner, and sites for these factors have been identified in the upstream promoter region (Nagarajan et al, 2001; Halder et al, 2002; LeBlanc et al, 2005; Jang et al, 2010).

Literature References
PubMed ID Title Journal Year
21044070 Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes

Nagarajan, R, Keles, S, Jones, EA, Sun, G, Chang, LW, Svaren, J, Jang, SW, Srinivasan, R, Krueger, C

J. Neurochem. 2010
15836632 Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination

Wrabetz, L, Gillian-Daniel, AL, Mager, GM, Ferri, C, Svaren, J, Leblanc, SE, Srinivasan, R

J. Neurochem. 2005
20149798 Structural basis of human CYP51 inhibition by antifungal azoles

Park, HW, Usanov, SA, Strushkevich, N

J. Mol. Biol. 2010
12145339 A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol 14alpha-demethylase gene (CYP51)

Fink, M, Halder, SK, Waterman, MR, Rozman, D

Mol Endocrinol 2002
11394999 EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression

Milbrandt, J, Watson, M, Le, N, Svaren, J, Nagarajan, R, Araki, T

Neuron 2001
8619637 The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols

Stromstedt, M, Waterman, MR, Rozman, D

Arch Biochem Biophys 1996
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
CYP51A1 gene:EGR2:SREBF2 dimer [nucleoplasm] (Homo sapiens)
Active Unit
SREBF2(1-484) [nucleoplasm]
EGR2 [nucleoplasm]
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-09-26)
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