CYP51A1 gene expression

Stable Identifier
R-HSA-9621404
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, endoplasmic reticulum membrane
ReviewStatus
5/5
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CYP51A1 gene expression
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CYP51A1 encodes lanosterol 14 alpha-demethylase, an enzyme involved in steroid biosynthesis (Stroemstedt et al, 1996; Strushkevich et al, 2010). CYP51A1 is upregulated during Schwann cell myelination in an EGR2- and SREBF2-dependent manner, and sites for these factors have been identified in the upstream promoter region (Nagarajan et al, 2001; Halder et al, 2002; LeBlanc et al, 2005; Jang et al, 2010).
Literature References
PubMed ID Title Journal Year
21044070 Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes

Jang, SW, Srinivasan, R, Jones, EA, Sun, G, Keles, S, Krueger, C, Chang, LW, Nagarajan, R, Svaren, J

J. Neurochem. 2010
15836632 Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination

Leblanc, SE, Srinivasan, R, Ferri, C, Mager, GM, Gillian-Daniel, AL, Wrabetz, L, Svaren, J

J. Neurochem. 2005
20149798 Structural basis of human CYP51 inhibition by antifungal azoles

Strushkevich, N, Usanov, SA, Park, HW

J. Mol. Biol. 2010
12145339 A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol 14alpha-demethylase gene (CYP51)

Halder, SK, Fink, M, Waterman, MR, Rozman, D

Mol Endocrinol 2002
11394999 EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression

Nagarajan, R, Svaren, J, Le, N, Araki, T, Watson, M, Milbrandt, J

Neuron 2001
8619637 The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols

Stromstedt, M, Rozman, D, Waterman, MR

Arch Biochem Biophys 1996
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
CYP51A1 gene:EGR2:SREBF2 dimer [nucleoplasm] (Homo sapiens)
Active Unit
EGR2 [nucleoplasm]
SREBF2(1-484) [nucleoplasm]
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-09-26)
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