CYP51A1 gene expression

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R-HSA-9621404
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Reaction [omitted]
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Homo sapiens
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CYP51A1 encodes lanosterol 14 alpha-demethylase, an enzyme involved in steroid biosynthesis (Stroemstedt et al, 1996; Strushkevich et al, 2010). CYP51A1 is upregulated during Schwann cell myelination in an EGR2- and SREBF2-dependent manner, and sites for these factors have been identified in the upstream promoter region (Nagarajan et al, 2001; Halder et al, 2002; LeBlanc et al, 2005; Jang et al, 2010).

Literature References
PubMed ID Title Journal Year
15836632 Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination

Leblanc, SE, Srinivasan, R, Ferri, C, Mager, GM, Gillian-Daniel, AL, Wrabetz, L, Svaren, J

J. Neurochem. 2005
21044070 Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes

Jang, SW, Srinivasan, R, Jones, EA, Sun, G, Keles, S, Krueger, C, Chang, LW, Nagarajan, R, Svaren, J

J. Neurochem. 2010
20149798 Structural basis of human CYP51 inhibition by antifungal azoles

Strushkevich, N, Usanov, SA, Park, HW

J. Mol. Biol. 2010
12145339 A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol 14alpha-demethylase gene (CYP51)

Halder, SK, Fink, M, Waterman, MR, Rozman, D

Mol Endocrinol 2002
11394999 EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression

Nagarajan, R, Svaren, J, Le, N, Araki, T, Watson, M, Milbrandt, J

Neuron 2001
8619637 The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols

Stromstedt, M, Rozman, D, Waterman, MR

Arch Biochem Biophys 1996
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