Reactome | EGR1 binds TRIB1 gene

EGR1 binds TRIB1 gene

Stable Identifier

R-HSA-9621385

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        EGR1 binds TRIB1 gene (Homo sapiens)

General

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Based on ChIP studies done in rat PC12 cells, EGR1 binds to promoter elements updstream of the TRIB1 gene to regulate NGF-dependent signaling (Mullenbrock et al, 2011; Adams et al, 2017).

Literature References

PubMed ID	Title	Journal	Year
28076410	Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells Kletsov, S, Cooper, GM, Elman, JS, Adams, KW, Lamm, RJ, Mullenbrock, S	PLoS ONE	2017
22065583	Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation Cooper, GM, Mullenbrock, S, Shah, J	J. Biol. Chem.	2011