CITED2 gene expression is stimulated by FOXO1,FOXO3

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R-HSA-9621242
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Homo sapiens
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FOXO1 and FOXO3 directly stimulate transcription of the CITED2 gene, encoding a transcription factor CITED2 (also known as MRG1). In erythroid cell progenitors, FOXO3-mediated induction of CITED2 transcription may require erythropoietin-induced formation of the complex of FOXO3 and STAT5 (Bakker et al. 2007). FOXO3-mediated induction of CITED2 in response to hypoxic stress prevents HIF1-induced apoptosis (Bakker et al. 2007). Upregulation of CITED2, mediated by FOXO1 and/or FOXO3, enables survival of cardiomyocytes under oxidative stress (Sengupta et al. 2011). Vascular insulin resistance in type 2 diabetes leads to FOXO1-mediated upregulation of CITED2, which interferes with HIF-induced angiogenesis (Wang et al. 2016).

Literature References
PubMed ID Title Journal Year
18158893 FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2

Bakker, WJ, Harris, IS, Mak, TW

Mol. Cell 2007
27561725 Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells

Wang, X, Lockhart, SM, Rathjen, T, Albadawi, H, Sørensen, D, O'Neill, BT, Dwivedi, N, Preil, SR, Beck, HC, Dunwoodie, SL, Watkins, MT, Rasmussen, LM, Rask-Madsen, C

Diabetes 2016
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