REST binds the VGF promoter

Stable Identifier
R-HSA-9621054
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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REST binds the VGF promoter
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RE1-silencing transcription factor (REST, also known as Neuron-restrictive silencer factor or NRSF) is a transcriptional repressor that binds to neuron-restrictive silencer elements (NRSEs) to inhibit transcription in non-neuronal cells and to temporally regulate expression in neuronal cells. REST interacts with 2 corepressor complexes, mSIN3 and CoREST, which recruit histone deacetylases to promoter regions (Schoenherr et al, 1995; Lunyak et al, 2002; Mulligan et al, 2008). Promoter analysis of the VGF gene identified a functional NRSE element spanning the transcriptional start site, and this element is bound by NRSF as assessed by ChIP. Mutations in the NRSE relieve transcriptional repression and overexpression of NRSF in rat PC12 cells suppresses VGF transcription (Moon et al, 2015).
Literature References
PubMed ID Title Journal Year
12399542 Corepressor-dependent silencing of chromosomal regions encoding neuronal genes

Lunyak, VV, Burgess, R, Prefontaine, GG, Nelson, C, Sze, SH, Chenoweth, J, Schwartz, P, Pevzner, PA, Glass, C, Mandel, G, Rosenfeld, MG

Science 2002
25569790 Transcriptional regulation of the neuropeptide VGF by the neuron-restrictive silencer factor/neuron-restrictive silencer element

Moon, SM, Kim, JS, Park, BR, Kim, DK, Kim, SG, Kim, HJ, Chun, HS, Lee, BK, Kim, CS

Neuroreport 2015
7871435 The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes

Schoenherr, CJ, Anderson, DJ

Science 1995
19061646 CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation

Mulligan, P, Westbrook, TF, Ottinger, M, Pavlova, N, Chang, B, Macia, E, Shi, YJ, Barretina, J, Liu, J, Howley, PM, Elledge, SJ, Shi, Y

Mol. Cell 2008
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Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-09-26)
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