RE1-silencing transcription factor (REST, also known as Neuron-restrictive silencer factor or NRSF) is a transcriptional repressor that binds to neuron-restrictive silencer elements (NRSEs) to inhibit transcription in non-neuronal cells and to temporally regulate expression in neuronal cells. REST interacts with 2 corepressor complexes, mSIN3 and CoREST, which recruit histone deacetylases to promoter regions (Schoenherr et al, 1995; Lunyak et al, 2002; Mulligan et al, 2008). Promoter analysis of the VGF gene identified a functional NRSE element spanning the transcriptional start site, and this element is bound by NRSF as assessed by ChIP. Mutations in the NRSE relieve transcriptional repression and overexpression of NRSF in rat PC12 cells suppresses VGF transcription (Moon et al, 2015).
Sze, SH, Prefontaine, GG, Pevzner, PA, Mandel, G, Schwartz, P, Glass, C, Rosenfeld, MG, Chenoweth, J, Nelson, C, Burgess, R, Lunyak, VV
Kim, SG, Lee, BK, Kim, JS, Chun, HS, Kim, DK, Park, BR, Kim, CS, Kim, HJ, Moon, SM
Anderson, DJ, Schoenherr, CJ
Macia, E, Howley, PM, Mulligan, P, Elledge, SJ, Chang, B, Shi, Y, Westbrook, TF, Shi, YJ, Barretina, J, Pavlova, N, Ottinger, M, Liu, J
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