TPH1 (Tryptophan hydroxylase 1) is one of two tryptophan hydroxlyase enzymes that catalyze the rate-limiting step in the synthesis of 5-HT (5-hydroxytryptamine or serotonin). TPH1 is expressed in the gut, the periphery and in the pineal gland and additionally has roles during neuronal development. In contrast, TPH2 is expressed at high levels in the brain and the gut (Walther et al, 2003; Côté et al, 2003; Nakamura et al, 2006). TPH1 has been shown to be a transcriptional target of EGR1 and is transcriptionally activated downstream of sustained NGF signaling (Grasberer et al, 2013; Mullenbrock et al, 2011; Adams et al, 2017).
Kletsov, S, Cooper, GM, Elman, JS, Adams, KW, Lamm, RJ, Mullenbrock, S
Hanoun, N, Ripoche, MA, Bayard, E, Mallet, J, Thévenot, E, Vodjdani, G, Darmon, M, Lechat, P, Saurini, F, Fromes, Y, Fligny, C, Hamon, M, Dandolo, L, Côté, F
Hörtnagl, H, Walther, DJ, Fink, H, Bashammakh, S, Voits, M, Bader, M, Peter, JU
Tsurui, H, Xiu, Y, Sawabe, K, Ohtsuji, M, Lin, QS, Hasegawa, H, Hirose, S, Nishimura, H, Sugawara, Y, Ohashi, A, Nakamura, K
Presson, AP, Grasberger, H, Shih, W, Karagiannides, I, Mayer, E, Pothoulakis, C, Newberry, RD, Chang, L, Merchant, JL, Sayuk, GS
Cooper, GM, Mullenbrock, S, Shah, J
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