TPH1 gene expression

Stable Identifier
R-HSA-9621048
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TPH1 gene expression
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TPH1 (Tryptophan hydroxylase 1) is one of two tryptophan hydroxlyase enzymes that catalyze the rate-limiting step in the synthesis of 5-HT (5-hydroxytryptamine or serotonin). TPH1 is expressed in the gut, the periphery and in the pineal gland and additionally has roles during neuronal development. In contrast, TPH2 is expressed at high levels in the brain and the gut (Walther et al, 2003; Côté et al, 2003; Nakamura et al, 2006). TPH1 has been shown to be a transcriptional target of EGR1 and is transcriptionally activated downstream of sustained NGF signaling (Grasberer et al, 2013; Mullenbrock et al, 2011; Adams et al, 2017).
Literature References
PubMed ID Title Journal Year
28076410 Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells

Kletsov, S, Cooper, GM, Elman, JS, Adams, KW, Lamm, RJ, Mullenbrock, S

PLoS ONE 2017
14597720 Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function

Hanoun, N, Ripoche, MA, Bayard, E, Mallet, J, Thévenot, E, Vodjdani, G, Darmon, M, Lechat, P, Saurini, F, Fromes, Y, Fligny, C, Hamon, M, Dandolo, L, Côté, F

Proc. Natl. Acad. Sci. U.S.A. 2003
12511643 Synthesis of serotonin by a second tryptophan hydroxylase isoform

Hörtnagl, H, Walther, DJ, Fink, H, Bashammakh, S, Voits, M, Bader, M, Peter, JU

Science 2003
16407550 Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels

Tsurui, H, Xiu, Y, Sawabe, K, Ohtsuji, M, Lin, QS, Hasegawa, H, Hirose, S, Nishimura, H, Sugawara, Y, Ohashi, A, Nakamura, K

J. Neurosci. 2006
24060757 Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes

Presson, AP, Grasberger, H, Shih, W, Karagiannides, I, Mayer, E, Pothoulakis, C, Newberry, RD, Chang, L, Merchant, JL, Sayuk, GS

Am. J. Gastroenterol. 2013
22065583 Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation

Cooper, GM, Mullenbrock, S, Shah, J

J. Biol. Chem. 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TPH1 gene:EGR1 [nucleoplasm] (Homo sapiens)
Active Unit
EGR1 [nucleoplasm]
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-09-26)
Cite Us!