Tissue Factor F3 (TF) is an intrinsic plasma membrane protein that initiates blood clotting upon injury to the blood vessel (reviewed in Smith et al, 2015). TF is highly expressed in the brain and other tissues where the consequences of unchecked bleeding are high (Fleck et al, 1990). TF expression is regulated in part by binding of EGR1 to cognate sites in the promoter, and EGR1-dependent transcription has been observed downstream of sustained NGF signaling as well as after treatment wtith phorbol 12-myristate 13-acetate (PMA) or serum (Mullenbrock et al, 2011; Adams et al, 2017; Cui et al, 1996).
Varki, N, Rapaport, SI, Rao, LV, Fleck, RA
Kletsov, S, Cooper, GM, Elman, JS, Adams, KW, Lamm, RJ, Mullenbrock, S
Travers, RJ, Smith, SA, Morrissey, JH
Smith, M, Huang, RP, Oeth, P, Mackman, N, Parry, GC, Adamson, ED, Larson, H, Cui, MZ
Cooper, GM, Mullenbrock, S, Shah, J
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