TF gene expression

Stable Identifier
R-HSA-9621042
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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TF gene expression
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Tissue Factor F3 (TF) is an intrinsic plasma membrane protein that initiates blood clotting upon injury to the blood vessel (reviewed in Smith et al, 2015). TF is highly expressed in the brain and other tissues where the consequences of unchecked bleeding are high (Fleck et al, 1990). TF expression is regulated in part by binding of EGR1 to cognate sites in the promoter, and EGR1-dependent transcription has been observed downstream of sustained NGF signaling as well as after treatment wtith phorbol 12-myristate 13-acetate (PMA) or serum (Mullenbrock et al, 2011; Adams et al, 2017; Cui et al, 1996).
Literature References
PubMed ID Title Journal Year
2237820 Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody

Varki, N, Rapaport, SI, Rao, LV, Fleck, RA

Thromb. Res. 1990
28076410 Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells

Kletsov, S, Cooper, GM, Elman, JS, Adams, KW, Lamm, RJ, Mullenbrock, S

PLoS ONE 2017
26018600 How it all starts: Initiation of the clotting cascade

Travers, RJ, Smith, SA, Morrissey, JH

Crit. Rev. Biochem. Mol. Biol. 2015
8576248 Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and EGR-1

Smith, M, Huang, RP, Oeth, P, Mackman, N, Parry, GC, Adamson, ED, Larson, H, Cui, MZ

J. Biol. Chem. 1996
22065583 Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation

Cooper, GM, Mullenbrock, S, Shah, J

J. Biol. Chem. 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TF gene:EGR1 [nucleoplasm] (Homo sapiens)
Active Unit
EGR1 [nucleoplasm]
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-09-26)
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