EGR1 binds the VGF gene

Stable Identifier
Reaction [binding]
Homo sapiens
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In neuronal cells, the VGF gene is induced by sustained NGF signaling, as well as by cyclic AMP and other agents, although to a lower degree (Salton et al, 1991a; Salton et al, 1991b; Mullenbrock et al, 2011). Promoter analysis of the VGF gene identified a proximal promoter element spanning nucleotides -180 to -70 with a number of consensus binding sequences for transcriptional regulators (Canu et al, 1997; Possenti et al, 1992; Di Rocco et al, 1997; D'Arcangelo et al, 1996). This promoter is under negative regulation in non-neuronal cells. Among the promoter elements identified is a G(S)G motif between the TATA box and the transcriptional start site that is bound by EGR1 in an NGF-inducible mannner (D'Arcangelo et al, 1996; Mullenbrock et al, 2011; Adams et al, 2017).

Literature References
PubMed ID Title Journal Year
9032251 Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific, neurotrophin-inducible vgf gene

Di Rocco, G, Pennuto, M, Illi, B, Nasi, S, Trani, E, Mandolesi, G, Sirinian, MI, Levi, A, Filocamo, G, Jucker, R, Possenti, R, Canu, N, Rinaldi, AM

Mol. Cell. Biol. 1997
28076410 Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells

Kletsov, S, Cooper, GM, Elman, JS, Adams, KW, Lamm, RJ, Mullenbrock, S

PLoS ONE 2017
1570299 Regulatory elements in the promoter region of vgf, a nerve growth factor-inducible gene

Di Rocco, G, Nasi, S, Levi, A, Possenti, R

Proc. Natl. Acad. Sci. U.S.A. 1992
2017159 Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells

Dong, KW, Fischberg, DJ, Salton, SR

Mol. Cell. Biol. 1991
22065583 Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation

Cooper, GM, Mullenbrock, S, Shah, J

J. Biol. Chem. 2011
1861162 Nucleotide sequence and regulatory studies of VGF, a nervous system-specific mRNA that is rapidly and relatively selectively induced by nerve growth factor

Salton, SR

J. Neurochem. 1991
8756618 Activation of codependent transcription factors is required for transcriptional induction of the vgf gene by nerve growth factor and Ras

D'Arcangelo, G, Salton, SR, Halegoua, S, Habas, R, Wang, S

Mol. Cell. Biol. 1996
9084409 Molecular cloning and characterization of the human VGF promoter region

Levi, A, Trani, E, Possenti, R, Canu, N, Rinaldi, AM

J. Neurochem. 1997
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