ARC binds DNM2 and SH3GL3

Stable Identifier
Reaction [binding]
Homo sapiens
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ARC mRNA is rapidly transported to active synapses during synaptic activity where it is locally translated (Steward et al, 1998). At the synapse, ARC protein oligomerizes into virion-like capsids and interacts directly with dynamin2 (DYN2) and endophilin (SH3GL3) to promote the internalization of AMPA receptors (Myrum et al, 2015; Chowdhury et al, 2006; Rial Verde et al, 2006). Because AMPA receptors are also known to transcriptionally inhibit ARC gene expression through a Gi-specific G protein mechanism, this establishes a negative feedback loop between ARC gene expression and cell surface localization of AMPA receptors. The details of this relationship remain to be elucidated (Rao et al, 2006; Mokin et al, 2003; reviewed in Epstein and Finkbeiner, 2018).

Literature References
PubMed ID Title Journal Year
9808461 Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites

Wallace, CS, Lyford, GL, Steward, O, Worley, PF

Neuron 1998
17088211 Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking

Worley, PF, Plath, N, Lyford, G, Shepherd, JD, Kuhl, D, Petralia, RS, Huganir, RL, Chowdhury, S, Okuno, H

Neuron 2006
29559111 The Arc of cognition: Signaling cascades regulating Arc and implications for cognitive function and disease

Epstein, I, Finkbeiner, S

Semin. Cell Dev. Biol. 2018
25748042 Arc is a flexible modular protein capable of reversible self-oligomerization

Haavik, J, Flydal, MI, Bramham, CR, Myrum, C, Martinez, A, Bustad, HJ, Soulé, J, Baumann, A, Mariaule, V, Alvira, S, Márquez, JA, Cuellar, J, Valpuesta, JM

Biochem. J. 2015
16339507 Immediate-early gene-encoded protein Arc is associated with synaptic delivery of GluR4-containing AMPA receptors during in vitro classical conditioning

Mokin, M, Lindahl, JS, Keifer, J

J. Neurophysiol. 2006
16732277 AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc

Chin, J, Mitra, S, Peebles, CL, Finkbeiner, S, Pintchovski, SA, Rao, VR

Nat. Neurosci. 2006
17088212 Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission

Lee-Osbourne, J, Rial Verde, EM, Cline, HT, Malinow, R, Worley, PF

Neuron 2006
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