ARC mRNA is rapidly transported to active synapses during synaptic activity where it is locally translated (Steward et al, 1998). At the synapse, ARC protein oligomerizes into virion-like capsids and interacts directly with dynamin2 (DYN2) and endophilin (SH3GL3) to promote the internalization of AMPA receptors (Myrum et al, 2015; Chowdhury et al, 2006; Rial Verde et al, 2006). Because AMPA receptors are also known to transcriptionally inhibit ARC gene expression through a Gi-specific G protein mechanism, this establishes a negative feedback loop between ARC gene expression and cell surface localization of AMPA receptors. The details of this relationship remain to be elucidated (Rao et al, 2006; Mokin et al, 2003; reviewed in Epstein and Finkbeiner, 2018).
Wallace, CS, Lyford, GL, Steward, O, Worley, PF
Worley, PF, Plath, N, Lyford, G, Shepherd, JD, Kuhl, D, Petralia, RS, Huganir, RL, Chowdhury, S, Okuno, H
Epstein, I, Finkbeiner, S
Haavik, J, Flydal, MI, Bramham, CR, Myrum, C, Martinez, A, Bustad, HJ, Soulé, J, Baumann, A, Mariaule, V, Alvira, S, Márquez, JA, Cuellar, J, Valpuesta, JM
Mokin, M, Lindahl, JS, Keifer, J
Chin, J, Mitra, S, Peebles, CL, Finkbeiner, S, Pintchovski, SA, Rao, VR
Lee-Osbourne, J, Rial Verde, EM, Cline, HT, Malinow, R, Worley, PF
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