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p-S516-ARHGEF7-1 [cytosol]
Stable Identifier
R-HSA-9619775
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Activation of RAC1 downstream of NMDARs (Homo sapiens)
CAMK1 phosphorylates ARHGEF7-1 (Homo sapiens)
GIT1:p-S516-ARHGEF7-1 [cytosol] (Homo sapiens)
p-S516-ARHGEF7-1 [cytosol] (Homo sapiens)
p-S516-ARHGEF7 activates RAC1 (Homo sapiens)
GIT1:p-S516-ARHGEF7-1 [cytosol] (Homo sapiens)
p-S516-ARHGEF7-1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14155-1 ARHGEF7
Gene Names
ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB, Nbla10314
Other Identifiers
11723129_a_at
11723130_a_at
11726073_a_at
11726074_a_at
11752571_a_at
11752845_a_at
11752846_x_at
16776537
202547_PM_s_at
202547_s_at
202548_PM_s_at
202548_s_at
229642_PM_at
229642_at
236416_PM_at
236416_at
242999_PM_at
242999_at
3501660
3501662
3501663
3501666
3501667
3501672
3501673
3501674
3501675
3501678
3501684
3501685
3501690
3501695
3501698
3501699
3501704
3501705
3501707
3501708
3501709
3501714
3501721
3501722
3501723
3501724
3501727
3501728
3501729
3501730
3501731
3501732
3501733
3501736
3501737
3501739
3501740
3501741
3501742
3501743
3501744
3501745
3501746
3501747
3501748
3501749
3501750
40828_at
42569_at
69169_at
7970111
81222_at
8874
A_14_P109119
A_23_P321855
A_23_P417891
A_33_P3288904
D63476_at
GE57273
GE647512
GE809705
GO:0000322
GO:0001726
GO:0002244
GO:0005085
GO:0005515
GO:0005737
GO:0005773
GO:0005813
GO:0005815
GO:0005829
GO:0005886
GO:0005925
GO:0005938
GO:0007030
GO:0007165
GO:0007266
GO:0007399
GO:0008092
GO:0010763
GO:0019901
GO:0030027
GO:0030032
GO:0030154
GO:0032991
GO:0034330
GO:0035556
GO:0042995
GO:0043005
GO:0043015
GO:0043025
GO:0043065
GO:0043226
GO:0043547
GO:0048013
GO:0048041
GO:0048856
GO:0060124
GO:0070161
GO:0097431
GO:0098772
GO:0098794
GO:1900026
GO:1905833
GO:2000394
HMNXSV003022798
HMNXSV003023162
Hs.117494.0.S1_3p_at
Hs.13625.0.A1_3p_at
Hs.172813.0.A1_3p_a_at
Hs.201919.0.A1_3p_at
ILMN_1675984
ILMN_1796912
ILMN_1798587
ILMN_2235679
PH_hs_0010346
RNA95435|RNS_517_159
TC13000398.hg
TC13001303.hg
g4505572_3p_a_at
Participates
as a component of
GIT1:p-S516-ARHGEF7-1 [cytosol] (Homo sapiens)
Other forms of this molecule
ARHGEF7-1 [cytosol]
Modified Residues
Name
O-phospho-L-serine at 516
Coordinate
516
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001106985.1
,
NP_003890.1
,
XP_016876314.1
,
NP_001307783.1
,
NP_001317526.1
,
NP_001307782.1
,
NP_663788.1
,
NP_001317527.1
,
XP_016876313.1
,
NP_001106984.1
,
NP_001106983.1
,
NP_001307780.1
OpenTargets
ENSG00000102606
ENSEMBL
ENSP00000325994
,
ENSP00000364888
,
ENST00000317133
,
ENSP00000397068
,
ENST00000426073
,
ENST00000375741
,
ENSP00000364893
,
ENSP00000364891
,
ENST00000375723
,
ENSP00000364875
,
ENST00000375736
,
ENST00000375739
HPA
ENSG00000102606-ARHGEF7
PRO
Q14155
Pharos - Targets
Q14155
GlyGen
Q14155
PDB
1ZSG
,
2L3G
,
1BY1
,
5SXP
HMDB Protein
HMDBP11481
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13153 PAK1
5
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
PAK1 [cytosol]
(R-HSA-162629)
Active PAK1 [cytosol]
(R-HSA-8964622)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
PAK1 [plasma membrane]
(R-HSA-3928409)
0.953
16
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.936
21
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.822
8
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.813
5
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
0.81
8
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.715
7
UniProt:P63000 RAC1
6
RAC1 [plasma membrane]
(R-HSA-351141)
RAC1 [cytosol]
(R-HSA-442615)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
0.676
8
UniProt:Q14161 GIT2
1
GIT2 [cytosol]
(R-HSA-446034)
0.669
5
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.643
3
UniProt:P60953-2 CDC42
0.623
3
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL [cytosol]
(R-HSA-112199)
p-Y371-CBL [cytosol]
(R-HSA-182940)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
0.591
9
UniProt:O60880-1 SH2D1A
0.581
5
UniProt:Q9NPJ6 MED4
1
MED4 [nucleoplasm]
(R-HSA-350263)
0.569
4
UniProt:P50222 MEOX2
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
GTP [ChEBI:15996]
7
GTP [cilium]
(R-ALL-5617813)
GTP [early endosome membrane]
(R-ALL-2130170)
GTP [lysosomal membrane]
(R-ALL-2213216)
GTP [platelet dense granule lumen]
(R-ALL-114625)
GTP [cytoplasmic vesicle membrane]
(R-ALL-1996291)
GTP [ER to Golgi transport vesicle membrane]
(R-ALL-983318)
GTP [Golgi membrane]
(R-ALL-1806221)
0.544
2
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.527
3
UniProt:Q15052 ARHGEF6
1
ARHGEF6 [cytosol]
(R-HSA-195017)
0.527
4
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.527
3
UniProt:P49023 PXN
4
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [plasma membrane]
(R-HSA-180493)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.527
3
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.527
4
UniProt:P41227 NAA10
0.524
3
UniProt:Q9BYB0 SHANK3
1
SHANK3 [cytosol]
(R-HSA-6794277)
0.508
2
UniProt:Q13191 CBLB
1
CBLB [cytosol]
(R-HSA-976009)
0.508
2
UniProt:P30153 PPP2R1A
2
PPP2R1A [cytosol]
(R-HSA-165982)
PPP2R1A [nucleoplasm]
(R-HSA-165968)
0.499
3
UniProt:Q7Z6B7 SRGAP1
1
SRGAP1 [cytosol]
(R-HSA-428453)
0.499
4
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.483
3
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