Reactome | p-S516-ARHGEF7-1 [cytosol]

p-S516-ARHGEF7-1 [cytosol]

Stable Identifier

R-HSA-9619775

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14155-1 ARHGEF7

Gene Names

ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB, Nbla10314

Other Identifiers

11723129_a_at

11723130_a_at

11726073_a_at

11726074_a_at

11752571_a_at

11752845_a_at

11752846_x_at

16776537

202547_PM_s_at

202547_s_at

202548_PM_s_at

202548_s_at

229642_PM_at

229642_at

236416_PM_at

236416_at

242999_PM_at

242999_at

3501660

3501662

3501663

3501666

3501667

3501672

3501673

3501674

3501675

3501678

3501684

3501685

3501690

3501695

3501698

3501699

3501704

3501705

3501707

3501708

3501709

3501714

3501721

3501722

3501723

3501724

3501727

3501728

3501729

3501730

3501731

3501732

3501733

3501736

3501737

3501739

3501740

3501741

3501742

3501743

3501744

3501745

3501746

3501747

3501748

3501749

3501750

40828_at

42569_at

69169_at

7970111

81222_at

8874

A_14_P109119

A_23_P321855

A_23_P417891

A_33_P3288904

D63476_at

GE57273

GE647512

GE809705

GO:0000322

GO:0001726

GO:0002244

GO:0005085

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005886

GO:0005925

GO:0005938

GO:0007030

GO:0007165

GO:0007266

GO:0007399

GO:0008092

GO:0010763

GO:0019901

GO:0030027

GO:0030032

GO:0030154

GO:0032991

GO:0034330

GO:0035556

GO:0042995

GO:0043005

GO:0043015

GO:0043025

GO:0043065

GO:0043547

GO:0048013

GO:0048041

GO:0048856

GO:0060124

GO:0070161

GO:0097431

GO:0098794

GO:1900026

GO:1905833

GO:2000394

HMNXSV003022798

HMNXSV003023162

Hs.117494.0.S1_3p_at

Hs.13625.0.A1_3p_at

Hs.172813.0.A1_3p_a_at

Hs.201919.0.A1_3p_at

ILMN_1675984

ILMN_1796912

ILMN_1798587

ILMN_2235679

PH_hs_0010346

RNA95435|RNS_517_159

TC13000398.hg

TC13001303.hg

g4505572_3p_a_at

Participates

as a component of

GIT1:p-S516-ARHGEF7-1 [cytosol] (Homo sapiens)

Other forms of this molecule

ARHGEF7-1 [cytosol]

Modified Residues

Name

O-phospho-L-serine at 516

Coordinate

516

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_663788.1, XP_047286688.1, XP_054231110.1, XP_054231111.1, NP_001307782.1, NP_001307783.1, NP_001317526.1, NP_001106985.1, XP_054231097.1, NP_001317527.1, NP_001106984.1, NP_001106983.1, NP_001340985.1, XP_047286699.1, NP_001340986.1, NP_001307780.1, XP_047286700.1, XP_047286701.1, NP_003890.1, NP_001340989.1, NP_001340988.1, NP_001340987.1, NP_001340982.1, NP_001340981.1, XP_054231109.1, XP_016876313.1, XP_016876314.1

OpenTargets

ENSG00000102606

ENSEMBL

ENSP00000364891, ENST00000426073, ENSP00000364893, ENST00000317133, ENST00000375723, ENSP00000364875, ENST00000375739, ENST00000375736, ENSP00000325994, ENSP00000364888, ENST00000375741, ENSP00000397068, ENSG00000102606

HPA

ENSG00000102606-ARHGEF7

GeneCards

ARHGEF7

PRO

Q14155

Pharos - Targets

Q14155

GlyGen

Q14155

PDB

2L3G, 1ZSG, 1BY1, 5SXP

HMDB Protein

HMDBP11481

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13153 PAK1	5	p-S144,T423-PAK1 [cytosol] (R-HSA-399819) PAK1 [cytosol] (R-HSA-162629) Active PAK1 [cytosol] (R-HSA-8964622) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [plasma membrane] (R-HSA-3928409)	0.953	16
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.936	20
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.822	8
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.813	5
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.81	8
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.715	7
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.676	8
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.671	5
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.669	5
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.643	5
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.643	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.643	3
UniProt:P60953-2 CDC42			0.623	3
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826)	0.591	9
UniProt:O60880-1 SH2D1A			0.581	5
UniProt:P50222 MEOX2			0.556	3
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.553	2
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.544	2
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.527	3
UniProt:P49023 PXN	4	p-Y31,Y118-PXN [cytosol] (R-HSA-5218693) PXN [cytosol] (R-HSA-210014) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493)	0.527	3
UniProt:Q3KP66 INAVA			0.527	3
UniProt:O60925 PFDN1	1	PFDN1 [cytosol] (R-HSA-379541)	0.527	3
UniProt:O14907 TAX1BP3	1	TAX1BP3 [cytosol] (R-HSA-5666217)	0.527	4
UniProt:Q15052 ARHGEF6	1	ARHGEF6 [cytosol] (R-HSA-195017)	0.527	4
UniProt:Q9NVF7 FBX28			0.527	4
UniProt:Q15599 NHRF2			0.527	2
UniProt:Q6P9G4 TM154			0.527	2
UniProt:O60711 LPXN			0.527	3
UniProt:Q9NZQ3 NCKIPSD	1	NCKIPSD [cytosol] (R-HSA-2197671)	0.527	2
UniProt:P41227 NAA10			0.524	3
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.508	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.508	2
UniProt:Q7Z6B7 SRGAP1	1	SRGAP1 [cytosol] (R-HSA-428453)	0.499	4
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.499	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.483	3

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