L-PRX:DRP2 binds dystroglycan and laminin-211

Stable Identifier
Reaction [binding]
Homo sapiens
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The DRP2:L-PRX complex interacts with dystroglycan in the plasma membrane as part of the dystrophin glycoprotein complex (DGC) (Sherman et al, 2001; Court et al 2009; Sherman et al, 2012). DGC complexes have structural and signaling roles and provide a connection between the abaxonal Schwann cell plasma membrane and the adjacent basal lamina through interaction with laminin complexes, including laminin-211 (Ervasti et al, 1993; Yamada et al, 1994; Yamada et al, 1996; Imamura et al, 2000; reviewed in Wrabetz and Feltri, 2001; Masaki and Matsumura, 2010).

Literature References
PubMed ID Title Journal Year
11430795 Do Schwann cells stop, DR(o)P2, and roll?

Wrabetz, L, Feltri, ML

Neuron 2001
8349731 A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin

Ervasti, JM, Campbell, KP

J. Cell Biol. 1993
11115854 A sarcoglycan-dystroglycan complex anchors Dp116 and utrophin in the peripheral nervous system

Ozawa, E, Noguchi, S, Araishi, K, Imamura, M

Hum. Mol. Genet. 2000
11430802 Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy

Gillespie, CS, Fabrizi, C, Brophy, PJ, Sherman, DL

Neuron 2001
8627307 Characterization of dystroglycan-laminin interaction in peripheral nerve

Matsumura, K, Kanazawa, I, Endo, T, Yamada, H, Fukuta-Ohi, H, Anderson, LV, Shimizu, T, Kobata, A, Hori, H, Chiba, A, Campbell, KP

J. Neurochem. 1996
19321787 A laminin-2, dystroglycan, utrophin axis is required for compartmentalization and elongation of myelin segments

Wrabetz, L, Hewitt, JE, Feltri, ML, Davies, K, Uncini, A, Court, FA, Patton, BL

J. Neurosci. 2009
7925941 Dystroglycan is a binding protein of laminin and merosin in peripheral nerve

Yamada, H, Matsumura, K, Shimizu, T, Tanaka, T, Campbell, KP

FEBS Lett. 1994
22764250 Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth

Gillespie, CS, Wu, LM, Grove, M, Brophy, PJ, Sherman, DL

J. Neurosci. 2012
20625412 Biological role of dystroglycan in Schwann cell function and its implications in peripheral nervous system diseases

Matsumura, K, Masaki, T

J. Biomed. Biotechnol. 2010
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