Reactome | L-PRX:DRP2 binds dystroglycan and laminin-211

L-PRX:DRP2 binds dystroglycan and laminin-211

Stable Identifier

R-HSA-9619666

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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L-PRX:DRP2 binds dystroglycan and laminin-211

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The DRP2:L-PRX complex interacts with dystroglycan in the plasma membrane as part of the dystrophin glycoprotein complex (DGC) (Sherman et al, 2001; Court et al 2009; Sherman et al, 2012). DGC complexes have structural and signaling roles and provide a connection between the abaxonal Schwann cell plasma membrane and the adjacent basal lamina through interaction with laminin complexes, including laminin-211 (Ervasti et al, 1993; Yamada et al, 1994; Yamada et al, 1996; Imamura et al, 2000; reviewed in Wrabetz and Feltri, 2001; Masaki and Matsumura, 2010).

Literature References

PubMed ID	Title	Journal	Year
11430795	Do Schwann cells stop, DR(o)P2, and roll? Wrabetz, L, Feltri, ML	Neuron	2001
8349731	A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin Ervasti, JM, Campbell, KP	J. Cell Biol.	1993
11115854	A sarcoglycan-dystroglycan complex anchors Dp116 and utrophin in the peripheral nervous system Imamura, M, Araishi, K, Noguchi, S, Ozawa, E	Hum. Mol. Genet.	2000
11430802	Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy Sherman, DL, Fabrizi, C, Gillespie, CS, Brophy, PJ	Neuron	2001
8627307	Characterization of dystroglycan-laminin interaction in peripheral nerve Yamada, H, Chiba, A, Endo, T, Kobata, A, Anderson, LV, Hori, H, Fukuta-Ohi, H, Kanazawa, I, Campbell, KP, Shimizu, T, Matsumura, K	J. Neurochem.	1996
19321787	A laminin-2, dystroglycan, utrophin axis is required for compartmentalization and elongation of myelin segments Court, FA, Hewitt, JE, Davies, K, Patton, BL, Uncini, A, Wrabetz, L, Feltri, ML	J. Neurosci.	2009
7925941	Dystroglycan is a binding protein of laminin and merosin in peripheral nerve Yamada, H, Shimizu, T, Tanaka, T, Campbell, KP, Matsumura, K	FEBS Lett.	1994
22764250	Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth Sherman, DL, Wu, LM, Grove, M, Gillespie, CS, Brophy, PJ	J. Neurosci.	2012
20625412	Biological role of dystroglycan in Schwann cell function and its implications in peripheral nervous system diseases Masaki, T, Matsumura, K	J. Biomed. Biotechnol.	2010