Reactome | CaMKKs phosphorylate CAMK1

CaMKKs phosphorylate CAMK1

Stable Identifier

R-HSA-9619367

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        Activation of RAC1 downstream of NMDARs (Homo sapiens)
        
        CaMKKs phosphorylate CAMK1 (Homo sapiens)

General

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Both CaMKKs, CAMKK1 (Haribabu et al. 1995) and CAMKK2 (Woods et al. 2005), phosphorylate CAMK1 on threonine residue T177 in a calmodulin-dependent manner.

Participants

Input

Output

Participant Of

hasEvent

Activation of RAC1 downstream of NMDARs

Catalyst Activity

Title

calmodulin-dependent protein kinase activity of p-CaMKK:CALM1:4xCa2+ [cytosol]

Physical Entity

p-CaMKK:CALM1:4xCa2+ [cytosol]

Activity

calmodulin-dependent protein kinase activity (0004683)

Inferred From

CAMKK2 phosphorylates Camk1 (Homo sapiens)

CAMKK1 phosphorylates CAMK1 (Homo sapiens)

Authored

Orlic-Milacic, M (2018-10-10)

Reviewed

Yi, F (2018-11-02)

Hansen, KB (2018-11-02)

Created

Orlic-Milacic, M (2018-09-14)