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Calcium binds calmodulin at the synapse
Stable Identifier
R-HSA-9618811
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Long-term potentiation (Homo sapiens)
Calcium binds calmodulin at the synapse (Homo sapiens)
General
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SBGN
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Upon NMDA receptor-mediated increase in calcium (Ca2+) concentration, calmodulin (CALM1, commonly labeled as CaM) is activated by binding to four calcium ions (Crouch and Klee 1980, DeLorenzo 1982). In neurons, CALM1 is concentrated at the synapse by binding to neurogranin (NRGN). After neuronal activation-induced influx of Ca2+, CALM1 dissociates from NRGN and binds to Ca2+ to activate downstream signaling. Dissociation of CALM1 from NRGN may be facilitated by PKC-mediated phosphorylation of NRGN (Zhong et al. 2009).
Participants
Input
x 4
Ca2+ [cytosol]
CALM1:NRGN [cytosol]
(Homo sapiens)
Output
CALM1:4xCa2+ [cytosol]
(Homo sapiens)
NRGN [cytosol]
(Homo sapiens)
Participates
as an event of
Long-term potentiation (Homo sapiens)
Inferred From
Calcium binds calmodulin (Bos taurus)
Calcium binds calmodulin at the synapse (Rattus norvegicus)
Authored
Orlic-Milacic, M (2018-10-10)
Reviewed
Hansen, KB (2018-11-02)
Yi, F (2018-11-02)
Created
Orlic-Milacic, M (2018-09-12)
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