SOX10, EGR2 and NAB proteins bind the GJB1 promoter

Stable Identifier
R-HSA-9618725
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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GJB1 expression is regulated by two alternate promoters in a tissue specific manner. In Schwann cells, expression is driven by the P2 promoter and depends on binding by SOX10, EGR2 and NAB1 or NAB2 (Neuhaus et al, 1996; Bondurand et al, 2001; Le et al, 2005; Lopez-Arido et al, 2015).

Literature References
PubMed ID Title Journal Year
11734543 Human Connexin 32, a gap junction protein altered in the X-linked form of Charcot-Marie-Tooth disease, is directly regulated by the transcription factor SOX10

Bondurand, N, Girard, M, Pingault, V, Lemort, N, Dubourg, O, Goossens, M

Hum. Mol. Genet. 2001
16136673 Nab proteins are essential for peripheral nervous system myelination

Le, N, Nagarajan, R, Wang, JY, Svaren, J, LaPash, C, Araki, T, Schmidt, RE, Milbrandt, J

Nat. Neurosci. 2005
25974668 Differential Sox10 genomic occupancy in myelinating glia

Lopez-Anido, C, Sun, G, Koenning, M, Srinivasan, R, Hung, HA, Emery, B, Keles, S, Svaren, J

Glia 2015
8842374 The human connexin32 gene is transcribed from two tissue-specific promoters

Neuhaus, IM, Bone, L, Wang, S, Ionasescu, V, Werner, R

Biosci. Rep. 1996
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