The transcription factor E2F1 in a complex with TFDP1 or TFDP2 binds two elements in the P2 promoter of the MYC gene and activates transcription (Hiebert et al. 1989, Thalmeier et al. 1989, Weinmann et al. 2001). An intact E2F1 binding site is required for activation of MYC by adenoviral E1a proteins (Hiebert et al. 1989, Thalmeier et al. 1989).