E2F1 binds the promoter of the MYC gene

Stable Identifier
R-HSA-9618586
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The transcription factor E2F1 in a complex with TFDP1 or TFDP2 binds two elements in the P2 promoter of the MYC gene and activates transcription (Hiebert et al. 1989, Thalmeier et al. 1989, Weinmann et al. 2001). An intact E2F1 binding site is required for activation of MYC by adenoviral E1a proteins (Hiebert et al. 1989, Thalmeier et al. 1989).

Literature References
PubMed ID Title Journal Year
11564866 Use of chromatin immunoprecipitation to clone novel E2F target promoters

Weinmann, AS, Bartley, SM, Zhang, T, Zhang, MQ, Farnham, PJ

Mol. Cell. Biol. 2001
2524830 E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor

Hiebert, SW, Lipp, M, Nevins, JR

Proc. Natl. Acad. Sci. U.S.A. 1989
2721961 Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoter

Thalmeier, K, Synovzik, H, Mertz, R, Winnacker, EL, Lipp, M

Genes Dev. 1989
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