NR1H2,3 binds the ARL4C gene

Stable Identifier
R-HSA-9618407
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
LXR binds the ARL4C gene
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NR1H2,3 binds the ARL4C gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cholesterol-loading or treatment with the synthetic agonists of liver X-receptors alpha (LXRα, NR1H3) and beta (LXRβ, NR1H2), such as T0901317 or GW3965, significantly induced the expression of ADP-ribosylation factor-like 4C (ARL4C or ARL7) in murine RAW 264.7 and human THP1 macrophage cell lines (Hong C et al. 2011; Engel T et al. 2004; Sun D et al. 2012). Similar regulation of ARL4C mRNA expression was observed in human peripheral blood-derived monocytes (Hong C et al. 2011). Sequence analysis of the ARL4C 5'-flanking region identified two LXR response elements (LXRE) containing variant direct repeats with a 4 nucleotide spacer (DR4) at –1405 bp and −5215 bp relative to the transcription start site (Hong C et al. 2011). Electrophoretic mobility shift assay showed that LXR:RXR heterodimers efficiently bind the putative ARL4C LXREs to regulate transcription from the promoter (Hong C et al. 2011).
Literature References
PubMed ID Title Journal Year
21187453 Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target

Salazar, JV, Marathe, C, Dhamko, H, Walczak, R, Hong, C, Bradley, MN, Tontonoz, P, Boyadjian, R

J. Lipid Res. 2011
15147902 ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export

Rust, S, Hobohm, U, Schlueter, B, Seedorf, U, Pech, M, Assmann, G, Lorkowski, S, Cullen, P, Engel, T, Bode, G, Lueken, A

FEBS Lett. 2004
Participants
Input
Output
Participates
as an event of
Authored
Shamovsky, V  (2018-01-19)
Reviewed
D'Eustachio, P  (2018-12-29)
Repa, JJ  (2019-08-09)
Cummins, CL  (2019-08-09)
Created
Shamovsky, V  (2018-09-06)
Cite Us!