NR1H2,3 binds the ARL4C gene

Stable Identifier
R-HSA-9618407
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
LXR binds the ARL4C gene
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Cholesterol-loading or treatment with the synthetic agonists of liver X-receptors alpha (LXRα, NR1H3) and beta (LXRβ, NR1H2), such as T0901317 or GW3965, significantly induced the expression of ADP-ribosylation factor-like 4C (ARL4C or ARL7) in murine RAW 264.7 and human THP1 macrophage cell lines (Hong C et al. 2011; Engel T et al. 2004; Sun D et al. 2012). Similar regulation of ARL4C mRNA expression was observed in human peripheral blood-derived monocytes (Hong C et al. 2011). Sequence analysis of the ARL4C 5'-flanking region identified two LXR response elements (LXRE) containing variant direct repeats with a 4 nucleotide spacer (DR4) at –1405 bp and −5215 bp relative to the transcription start site (Hong C et al. 2011). Electrophoretic mobility shift assay showed that LXR:RXR heterodimers efficiently bind the putative ARL4C LXREs to regulate transcription from the promoter (Hong C et al. 2011).

Literature References
PubMed ID Title Journal Year
15147902 ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export

Engel, T, Lueken, A, Bode, G, Hobohm, U, Lorkowski, S, Schlueter, B, Rust, S, Cullen, P, Pech, M, Assmann, G, Seedorf, U

FEBS Lett. 2004
21187453 Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target

Hong, C, Walczak, R, Dhamko, H, Bradley, MN, Marathe, C, Boyadjian, R, Salazar, JV, Tontonoz, P

J. Lipid Res. 2011
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