FOXO:SMAD complex binds CDKN1A gene promoter

Stable Identifier
R-HSA-9618004
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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FOXO:SMAD complex binds CDKN1A gene promoter
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The complex of phosphorylated SMAD2/3 and SMAD4, bound to FOXO3, binds to the promoter of the CDKN1A gene. The p-2S-SMAD2/3:SMAD4 complex bound to FOXO1 or FOXO4 can probably also bind to the CDKN1A gene promoter. FOXG1 binding to the FOXO:SMAD complex inhibits FOXO:SMAD-mediated upregulation of CDKN1A transcription. FOXG1 plays an important role in sustained proliferation of telencephalic neuroepithelial progenitor cells (Seoane et al. 2004).
Literature References
PubMed ID Title Journal Year
15084259 Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

Massague, J, Shen, L, Le, HV, Anderson, SA, Seoane, J

Cell 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
FOXG1 [nucleoplasm] (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-08-31)
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