The complex of phosphorylated SMAD2/3 and SMAD4, bound to FOXO3, binds to the promoter of the CDKN1A gene. The p-2S-SMAD2/3:SMAD4 complex bound to FOXO1 or FOXO4 can probably also bind to the CDKN1A gene promoter. FOXG1 binding to the FOXO:SMAD complex inhibits FOXO:SMAD-mediated upregulation of CDKN1A transcription. FOXG1 plays an important role in sustained proliferation of telencephalic neuroepithelial progenitor cells (Seoane et al. 2004).
Seoane, J, Le, HV, Shen, L, Anderson, SA, Massague, J
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