FOXO4 binds ATXN3

Stable Identifier
R-HSA-9617927
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Endogenous human FOXO4 forms a complex with endogenous human ATXN3 (Araujo et al. 2011), a deubiquitinase involved in protein homeostasis, transcription, cytoskeleton regulation and myogenesis (reviewed in Matos et al. 2018). ATXN3, however, does not deubiquitinate FOXO4. FOXO4 is not recruited to ATXN3-containing nuclear inclusions in spinocerebellar ataxia type 3 (SCA3) (Araujo et al. 2011).

Literature References
PubMed ID Title Journal Year
21536589 FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3

Araujo, J, Breuer, P, Dieringer, S, Krauss, S, Dorn, S, Zimmermann, K, Pfeifer, A, Klockgether, T, Wuellner, U, Evert, BO

Hum. Mol. Genet. 2011
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