FOXO4 binds ATXN3

Stable Identifier
R-HSA-9617927
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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FOXO4 binds ATXN3
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Endogenous human FOXO4 forms a complex with endogenous human ATXN3 (Araujo et al. 2011), a deubiquitinase involved in protein homeostasis, transcription, cytoskeleton regulation and myogenesis (reviewed in Matos et al. 2018). ATXN3, however, does not deubiquitinate FOXO4. FOXO4 is not recruited to ATXN3-containing nuclear inclusions in spinocerebellar ataxia type 3 (SCA3) (Araujo et al. 2011).

Literature References
PubMed ID Title Journal Year
21536589 FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3

Araujo, J, Breuer, P, Dieringer, S, Krauss, S, Dorn, S, Zimmermann, K, Pfeifer, A, Klockgether, T, Wuellner, U, Evert, BO

Hum. Mol. Genet. 2011
Participants
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Orthologous Events
FOXO4 binds ATXN3 (Bos taurus)
FOXO4 binds ATXN3 (Caenorhabditis elegans)
FOXO4 binds ATXN3 (Canis familiaris)
FOXO4 binds ATXN3 (Danio rerio)
FOXO4 binds ATXN3 (Gallus gallus)
FOXO4 binds ATXN3 (Mus musculus)
FOXO4 binds ATXN3 (Rattus norvegicus)
FOXO4 binds ATXN3 (Sus scrofa)
FOXO4 binds ATXN3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Donlon, T  (2018-10-17)
Bertaggia, E  (2018-10-26)
Created
Orlic-Milacic, M  (2018-08-31)