Reactome | FOXO4 binds ATXN3

FOXO4 binds ATXN3

Stable Identifier

R-HSA-9617927

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Endogenous human FOXO4 forms a complex with endogenous human ATXN3 (Araujo et al. 2011), a deubiquitinase involved in protein homeostasis, transcription, cytoskeleton regulation and myogenesis (reviewed in Matos et al. 2018). ATXN3, however, does not deubiquitinate FOXO4. FOXO4 is not recruited to ATXN3-containing nuclear inclusions in spinocerebellar ataxia type 3 (SCA3) (Araujo et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21536589	FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3 Evert, BO, Araujo, J, Dorn, S, Dieringer, S, Wuellner, U, Krauss, S, Pfeifer, A, Klockgether, T, Breuer, P, Zimmermann, K	Hum. Mol. Genet.	2011