CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4

Stable Identifier
R-HSA-9617838
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4
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FOXO1, FOXO3 and FOXO4 stimulate transcription from the CDKN1A gene promoter. In response to TGF-beta signaling, FOXO transcription factors may cooperate with the active SMAD2/3:SMAD4 complexes to upregulate CDKN1A transcription (Seoane et al. 2004). FOXO1-mediated induction of CDKN1A gene transcription is implicated in CDKN1A upregulation in liver cells during fasting (Tinkum et al. 2013). Acetylation of FOXO4 by EP300 (p300) or CREBBP (CBP) in response to oxidative stress does not affect FOXO4-mediated induction of CDKN1A gene transcription (Dansen et al. 2009).
Literature References
PubMed ID Title Journal Year
15084259 Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

Massague, J, Shen, L, Le, HV, Anderson, SA, Seoane, J

Cell 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4:CDKN1A gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm]
Regulator
FOXO1,FOXO3,FOXO4:CDKN1A gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO1,FOXO3,FOXO4 [nucleoplasm]
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-08-30)
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