Reactome | p-T286-CaMKII dodecamer [cytosol]

p-T286-CaMKII dodecamer [cytosol]

Stable Identifier

R-HSA-9617584

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T286-CAMK2 dodecamer

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKII autophosphorylates (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAF activation (Homo sapiens)
        
        Phosphorylation of RAF (Homo sapiens)
        
        RAF activating kinases [plasma membrane] (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKII autophosphorylates (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)

General

CaMKII is composed of a homo or hetero dodecamer of four subunits apha, beta, delta and gamma. In a heteromultimer the ratio of alpha to beta may vary from 6;1, 3:1 or 1:1.

Participants

components

x 12 p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)

Participates

as a component of

p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)

Inferred To

p-T286-CaMKII dodecamer [cytosol] (Bos taurus)

p-T286-CaMKII dodecamer [cytosol] (Caenorhabditis elegans)

p-T286-CaMKII dodecamer [cytosol] (Canis familiaris)

p-T286-CaMKII dodecamer [cytosol] (Drosophila melanogaster)

p-T286-CaMKII dodecamer [cytosol] (Gallus gallus)

p-T286-CaMKII dodecamer [cytosol] (Mus musculus)

p-T286-CaMKII dodecamer [cytosol] (Rattus norvegicus)

p-T286-CaMKII dodecamer [cytosol] (Sus scrofa)