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Phospho-CREB1 binds the promoter of the CEBPB gene
Stable Identifier
R-HSA-9617217
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
Phospho-CREB1 binds the promoter of the CEBPB gene (Homo sapiens)
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CREB1 that is phosphorylated in response to CSF2 (GM-CSF) binds cyclic AMP responsive elements (CREs) in the promoter of the CEBPB gene (inferred from mouse homologs). Transcription of CEBPB is activated during "emergency granulopoiesis" by cytokines produced in response to bacterial infection.
Participants
Input
CEBPB gene [nucleoplasm]
(Homo sapiens)
p-S133-CREB1 homodimer [nucleoplasm]
(Homo sapiens)
Output
CEBPB gene:p-S133-CREB1 dimer [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Transcriptional regulation of granulopoiesis (Homo sapiens)
Inferred From
Phospho-Creb1 binds the promoter of the Cebpb gene (Mus musculus)
Authored
May, B (2018-08-16)
Reviewed
Skokowa, J (2019-03-10)
Created
May, B (2018-08-17)
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