CEBPB gene transcription is enhanced by phospho-CREB1 and phospho-STAT3

Stable Identifier
R-HSA-9617209
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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CEBPB gene transcription is enhanced by phospho-CREB1 and phospho-STAT3
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During emergency granulopoiesis triggered by bacterial infection, transcription of CEBPB is activated by the cytokines CSF2 (GM-CSF) and CSF3 (G-CSF): CSF2 acts via CSF2R and causes phosphorylation of CREB1, which then binds the promoter of the CEBPB gene (inferred from mouse homologs) while CSF3 acts via CSF3R and causes phosphorylation of STAT3, which also binds the promoter of the CEBPB gene (inferred from mouse homologs). Both phospho-CREB1 and phospho-STAT3 activate transcription of CEBPB (inferred from mouse homologs).
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
CEBPB gene:p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Regulator
CEBPB gene:p-S133-CREB1 dimer [nucleoplasm] (Homo sapiens)
Inferred From
Cebpb gene transcription is enhanced by phospho-Creb1 and phospho-Stat3 (Mus musculus)
Authored
May, B  (2018-08-16)
Reviewed
Skokowa, J  (2019-03-10)
Created
May, B  (2018-08-17)
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