CEBPB gene transcription is enhanced by phospho-CREB1 and phospho-STAT3

Stable Identifier
R-HSA-9617209
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

During emergency granulopoiesis triggered by bacterial infection, transcription of CEBPB is activated by the cytokines CSF2 (GM-CSF) and CSF3 (G-CSF): CSF2 acts via CSF2R and causes phosphorylation of CREB1, which then binds the promoter of the CEBPB gene (inferred from mouse homologs) while CSF3 acts via CSF3R and causes phosphorylation of STAT3, which also binds the promoter of the CEBPB gene (inferred from mouse homologs). Both phospho-CREB1 and phospho-STAT3 activate transcription of CEBPB (inferred from mouse homologs).

Participants
Participant Of
This event is regulated
Inferred From
Authored
Reviewed
Created
Cite Us!