All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene

Stable Identifier
R-HSA-9617067
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene
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The RARA:RXR heterodimeric retinoic acid receptor binds a retinoic acid receptor element (RARE) in the promoter of the CEBPE gene (Park et al. 1999). Retinoic acid binds RARA:RXR at the CEBPE gene and activates transcription of CEBPE (Park et al. 1999).
Literature References
PubMed ID Title Journal Year
10330422 CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment

Vuong, PT, Park, DJ, Miller, WH, Koeffler, HP, Gombart, AF, Chih, DY, Chumakov, AM

J. Clin. Invest. 1999
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Orthologous Events
All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Bos taurus)
All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Caenorhabditis elegans)
All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Canis familiaris)
All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Danio rerio)
All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Drosophila melanogaster)
All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Gallus gallus)
All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Mus musculus)
All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Rattus norvegicus)
All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Sus scrofa)
Authored
May, B  (2018-08-15)
Reviewed
Skokowa, J  (2019-03-10)
Created
May, B  (2018-08-16)
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