Reactome | Polyglutamyl-TUBA3D [cytosol]

Polyglutamyl-TUBA3D [cytosol]

Stable Identifier

R-HSA-9617013

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - CCPs deglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA3C/3D [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA3D [cytosol] (Homo sapiens)
    - Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA3C/3D [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA3D [cytosol] (Homo sapiens)
    - TTLLs polyglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA3C/3D [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA3D [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P0DPH8 TUBA3C

Gene Names

TUBA3C, TUBA2, TUBA3D

Chain

chain:1-450, chain:1-449

Reference Genes

BioGPS Gene:113457 TUBA3C

COSMIC (genes):TUBA3C TUBA3C

CTD Gene:113457 TUBA3C

dbSNP Gene:113457 TUBA3C

ENSEMBL:ENSG00000075886 TUBA3C

ENSEMBL_homo_sapiens_GENE:ENSG00000075886.11 TUBA3C

HGNC:24071 TUBA3C

KEGG Gene (Homo sapiens):113457 TUBA3C

KEGG Gene (Homo sapiens):7278 TUBA3C

Monarch:113457 TUBA3C

NCBI Gene:113457 TUBA3C

OMIM:617878 TUBA3C

Reference Transcript

RefSeq:NM_080386.3 TUBA3C

Other Identifiers

113457

11731689_x_at

16885726

216323_PM_x_at

216323_x_at

2506188

2506190

2506192

2506193

2506194

2506195

2506196

2506197

2506198

2506199

2506200

2575951

2575953

2575954

2575955

2575957

2575958

2575959

2575960

3503751

3503754

3503756

3503762

38350_f_at

685_f_at

8045291

A_23_P56736

A_32_P10003

GO:0000166

GO:0000226

GO:0000278

GO:0003824

GO:0005198

GO:0005200

GO:0005525

GO:0005737

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0015630

GO:0016787

GO:0043226

GO:0046872

HMNXSV003046205

HMNXSV003057359

Hs.75318.1.S1_3p_s_at

ILMN_2215639

ILMN_2215640

PH_hs_0029815

PH_hs_0033559

TC02000853.hg

TC02002321.hg

Participates

as a member of

Polyglutamyl-TUBA3C/3D [cytosol] (Homo sapiens)

Other forms of this molecule

Ac K40 TUBA3D [cytosol]

Ac K40 TUBA3D [axonemal microtubule]

TUBA3D folding intermediate [cytosol]

TUBA3D unfolded [cytosol]

L-isoglutamyl polyglycyl-TUBA3D [cytosol]

TUBA3D(1-449) [cytosol]

TUBA3D [axonemal microtubule]

TUBA3D [cytosol]

Inferred To

LOC608051 [cytosol] (Canis familiaris)

LOC100510930 [cytosol] (Sus scrofa)

Polyglutamyl-TUBA3C [cytosol] (Dictyostelium discoideum)

Polyglutamyl-TUBA3C [cytosol] (Plasmodium falciparum)

Homologues of Polyglutamyl-TUBA3C [cytosol] (Plasmodium falciparum)

Polyglutamyl-TUBA3D [cytosol] (Mus musculus)

Polyglutamyl-TUBA3D [cytosol] (Rattus norvegicus)

Modified Residues

Name

L-isoglutamyl-polyglutamic acid at unknown position

PsiMod Name

L-isoglutamyl-polyglutamic acid

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.

Cross References

RefSeq

NP_525125.2

OpenTargets

ENSG00000198033

GeneCards

P0DPH8

HPA

ENSG00000075886-TUBA3D

Ensembl

ENSP00000326042, ENSG00000075886, ENST00000321253

PRO

P0DPH8

Pharos - Targets

P0DPH8