CDK5R1 (also known as p35) is a neuron-specific regulator of CDK5 that activates CDK5 kinase. The complex of CDK5:CDK5R1 is required for neurite outgrowth (Tsai et al, 1994; Lew et al, 1994; Nikolic et al, 1996; Xiong et al, 1997; Paglini et al, 1998). CDK5R1 expression is regulated in part by the binding of EGR1 to its cognate binding sites in the CDK5R1 promoter. EGR1 binding is stimulated by sustained NGF signaling and depends on activation of the ERK signaling pathway (Harada et al, 2001).
Kunda, P, Paglini, G, Morfini, G, Caceres, A, Maccioni, R, Pigino, G, Ferreira, A, Quiroga, S
Rosner, MR, Pestell, R, Xiong, W
Lew, J, Wang, JH, Aebersold, R, Huang, QQ, Hunt, T, Qi, Z, Winkfein, RJ
Chae, T, Caviness, VS, Harlow, E, Delalle, I, Tsai, LH
Kwon, YT, Dudek, H, Tsai, LH, Nikolic, M, Ramos, YF
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