EGR1-dependent CDK5R1 gene expression

Stable Identifier
R-HSA-9616110
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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EGR1-dependent CDK5R1 gene expression
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CDK5R1 (also known as p35) is a neuron-specific regulator of CDK5 that activates CDK5 kinase. The complex of CDK5:CDK5R1 is required for neurite outgrowth (Tsai et al, 1994; Lew et al, 1994; Nikolic et al, 1996; Xiong et al, 1997; Paglini et al, 1998). CDK5R1 expression is regulated in part by the binding of EGR1 to its cognate binding sites in the CDK5R1 promoter. EGR1 binding is stimulated by sustained NGF signaling and depends on activation of the ERK signaling pathway (Harada et al, 2001).
Literature References
PubMed ID Title Journal Year
9822744 Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth

Paglini, G, Pigino, G, Kunda, P, Morfini, G, Maccioni, R, Quiroga, S, Ferreira, A, Caceres, A

J. Neurosci. 1998
9343422 Role of cyclins in neuronal differentiation of immortalized hippocampal cells

Xiong, W, Pestell, R, Rosner, MR

Mol. Cell. Biol. 1997
8090222 A brain-specific activator of cyclin-dependent kinase 5

Lew, J, Huang, QQ, Qi, Z, Winkfein, RJ, Aebersold, R, Hunt, T, Wang, JH

Nature 1994
8090221 p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

Tsai, LH, Delalle, I, Caviness, VS, Chae, T, Harlow, E

Nature 1994
8846918 The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

Nikolic, M, Dudek, H, Kwon, YT, Ramos, YF, Tsai, LH

Genes Dev. 1996
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
CDK5R1 gene:EGR1:NAB2 [nucleoplasm] (Homo sapiens)
Active Unit
EGR1 [nucleoplasm]
NAB2 [nucleoplasm]
Positively by
Regulator
CDK5R1 gene:EGR1 [nucleoplasm] (Homo sapiens)
Active Unit
EGR1 [nucleoplasm]
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-08-09)
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