EGR1 binds to its cognate site in the promoter element of the CDK5R1 gene in response to sustained stimulation with NGF. Expression of CDK5R1 (also known as p35) depends on activation of the ERK signaling pathway downstream of NGF stimulation, and is required to promote neurite outgrowth (Harada et al, 2001). CDK5R1 is a neuron-specific activator of CDK5, and the CDK5:CDK5R1 complex is required for neuronal differentiation (Tsai et al, 1994; Lew et al, 1994; Nikolic et al, 1996; Xiong et al, 1997; Paglini et al, 1998).
Kunda, P, Paglini, G, Morfini, G, Caceres, A, Maccioni, R, Pigino, G, Ferreira, A, Quiroga, S
Rosner, MR, Pestell, R, Xiong, W
Lew, J, Wang, JH, Aebersold, R, Huang, QQ, Hunt, T, Qi, Z, Winkfein, RJ
Chae, T, Caviness, VS, Harlow, E, Delalle, I, Tsai, LH
Harada, T, Nishida, E, Ogawa, S, Morooka, T
Kwon, YT, Dudek, H, Tsai, LH, Nikolic, M, Ramos, YF
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