EGR1 binds CDK5R1 gene

Stable Identifier
R-HSA-9616105
Type
Reaction [binding]
Species
Homo sapiens
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EGR1 binds to its cognate site in the promoter element of the CDK5R1 gene in response to sustained stimulation with NGF. Expression of CDK5R1 (also known as p35) depends on activation of the ERK signaling pathway downstream of NGF stimulation, and is required to promote neurite outgrowth (Harada et al, 2001). CDK5R1 is a neuron-specific activator of CDK5, and the CDK5:CDK5R1 complex is required for neuronal differentiation (Tsai et al, 1994; Lew et al, 1994; Nikolic et al, 1996; Xiong et al, 1997; Paglini et al, 1998).

Literature References
PubMed ID Title Journal Year
9343422 Role of cyclins in neuronal differentiation of immortalized hippocampal cells

Xiong, W, Pestell, R, Rosner, MR

Mol. Cell. Biol. 1997
9822744 Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth

Paglini, G, Pigino, G, Kunda, P, Morfini, G, Maccioni, R, Quiroga, S, Ferreira, A, Caceres, A

J. Neurosci. 1998
8090222 A brain-specific activator of cyclin-dependent kinase 5

Lew, J, Huang, QQ, Qi, Z, Winkfein, RJ, Aebersold, R, Hunt, T, Wang, JH

Nature 1994
8090221 p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

Tsai, LH, Delalle, I, Caviness, VS, Chae, T, Harlow, E

Nature 1994
11331872 ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1

Harada, T, Morooka, T, Ogawa, S, Nishida, E

Nat. Cell Biol. 2001
8846918 The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

Nikolic, M, Dudek, H, Kwon, YT, Ramos, YF, Tsai, LH

Genes Dev. 1996
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