PTEN mRNA translation is inhibited by miR-137

Stable Identifier
R-HSA-9615571
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PTEN mRNA translation is inhibited by miR-137
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Based on studies in both human and mouse model systems, translation of PTEN mRNA is inhibited by microRNA miR-137 (Lyu et al. 2016, Thomas et al. 2017).
Literature References
PubMed ID Title Journal Year
26843422 Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs

Lyu, JW, Yuan, B, Cheng, TL, Qiu, ZL, Zhou, WH

Sci Rep 2016
28683304 Inhibition of the Schizophrenia-Associated MicroRNA miR-137 Disrupts Nrg1α Neurodevelopmental Signal Transduction

Thomas, KT, Anderson, BR, Shah, N, Zimmer, SE, Hawkins, D, Valdez, AN, Gu, Q, Bassell, GJ

Cell Rep 2017
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
PTEN mRNA:miR-137 RISC [cytosol] (Homo sapiens)
Active Unit
miR-137 RISC [cytosol]
Authored
Orlic-Milacic, M  (2018-08-08)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2018-08-07)
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