miR-137 binds PTEN mRNA

Stable Identifier
R-HSA-9615570
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Based on sequence complementarity and 3'UTR luciferase reporter assays in both human and mouse model systems, microRNA miR-137 binds the 3'UTR of PTEN mRNA (Lyu et al. 2016, Thomas et al. 2017). It is uncertain whether miR-137 functions within the nonendonucleolytic or the endonucleolytic RISC or both.

Literature References
PubMed ID Title Journal Year
28683304 Inhibition of the Schizophrenia-Associated MicroRNA miR-137 Disrupts Nrg1α Neurodevelopmental Signal Transduction

Thomas, KT, Anderson, BR, Shah, N, Zimmer, SE, Hawkins, D, Valdez, AN, Gu, Q, Bassell, GJ

Cell Rep 2017
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