miR-137 binds PTEN mRNA

Stable Identifier
R-HSA-9615570
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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miR-137 binds PTEN mRNA
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Based on sequence complementarity and 3'UTR luciferase reporter assays in both human and mouse model systems, microRNA miR-137 binds the 3'UTR of PTEN mRNA (Lyu et al. 2016, Thomas et al. 2017). It is uncertain whether miR-137 functions within the nonendonucleolytic or the endonucleolytic RISC or both.
Literature References
PubMed ID Title Journal Year
28683304 Inhibition of the Schizophrenia-Associated MicroRNA miR-137 Disrupts Nrg1α Neurodevelopmental Signal Transduction

Thomas, KT, Anderson, BR, Shah, N, Zimmer, SE, Hawkins, D, Valdez, AN, Gu, Q, Bassell, GJ

Cell Rep 2017
Participants
Input
Output
Participates
as an event of
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2018-08-07)
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