miR-23b Endonucleolytic Minimal RISC [cytosol]

Stable Identifier
R-HSA-9614881
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
Argonaute2: miR-23b (single-stranded)
Locations in the PathwayBrowser
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General
The RNA-induced silencing complex contains an Argonaute (AGO) protein, whose PAZ domain binds the 3' end of the miRNA. The PIWI domain of AGO is responsible for cleavage of target RNAs, that is, RNAs complementary to the miRNA. Only AGO2 (EIF2C2) is capable of cleavage, however. AGO1 (EIF2C1), AGO3 (EIF2C3), and AGO4 (EIF2C4) repress translation of target RNAs by binding without cleavage.
Participants
components
Participates
as a component of
Inferred To
miR-23b Endonucleolytic Minimal RISC [cytosol] (Bos taurus)
miR-23b Endonucleolytic Minimal RISC [cytosol] (Canis familiaris)
miR-23b Endonucleolytic Minimal RISC [cytosol] (Drosophila melanogaster)
miR-23b Endonucleolytic Minimal RISC [cytosol] (Mus musculus)
miR-23b Endonucleolytic Minimal RISC [cytosol] (Rattus norvegicus)
miR-23b Endonucleolytic Minimal RISC [cytosol] (Sus scrofa)
miR-23b Endonucleolytic Minimal RISC [cytosol] (Xenopus tropicalis)
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