Transcriptional Activation of the HCMV Genome

Stable Identifier
R-HSA-9614811
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
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Cells infected by with the human cytomegalovirus (HCMV) have two potential fates once the HCMV genome enters the nucleus. In an active infection there is extensive viral gene expression, viral DNA replication and release of progeny virus. In contrast, in a latent infection the lytic transcription programme of HCMV is effectively suppressed and the cells undergo latent infection. The suppression of viral lytic gene expression observed during latency is the result from the cells inability to support robust viral immediate early (IE) gene expression; crucial genes responsible for driving the lytic cycle. The repression of IE gene expression results from specific post-translational modifications of histones associated with the viral major immediate early promoter (MIEP). The histone modifications present on the MIEP impart a repressive chromatin structure preventing transcriptional activity.

Literature References
PubMed ID Title Journal Year
19682613 Chromatin structure regulates human cytomegalovirus gene expression during latency, reactivation and lytic infection

Sinclair, J

Biochim. Biophys. Acta 2010
26572645 Cytomegalovirus latency and reactivation: recent insights into an age old problem

Dupont, L, Reeves, MB

Rev. Med. Virol. 2016
28415052 Viral gene products actively promote latent infection by epigenetic silencing mechanisms

Knipe, DM, Raja, P, Lee, J

Curr Opin Virol 2017
30761409 HCMV latency: what regulates the regulators?

Elder, E, Sinclair, J

Med. Microbiol. Immunol. 2019
  Fields Virology

Knipe, DM, Howley, PM

  2013
27501258 Human Cytomegalovirus Latency: Approaching the Gordian Knot

Goodrum, F

Annu Rev Virol 2016
Participants
Participant Of
Disease
Name Identifier Synonyms
viral infectious disease 934 arbovirus infectious disease, Viral disease, Viral infection NOS, Viral infection, unspecified (disorder), Viral infection NOS, Viral disease (disorder), Viral disease, Viral infection NOS (disorder), Viral Infection, virus infection, virus infection, Viral: [infection NOS] or [illness]
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