MBP gene expression

Stable Identifier
R-HSA-9614773
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
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MBP gene expression
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Myelin basic protein (MBP) is a key component of the myelin sheath synthesized by Schwan cells in the peripheral nervous system (Garbay et al, 2000). MBP expression is regulated by EGR2, which binds to both to an upstream enhancer and to sites within the first intron of the MBP gene (Forgahni et al, 2001; Denarier et al, 2005; Jang et al, 2006). Consistent with this, MBP expression is decreased in EGR2 knockout mice (Topilko et al, 1994, Le et al, 2005). Sequence analysis suggests that, as is the case for MPZ, SOX10 may act in conjunction with EGR2 to regulate MBP expression (Jones et al, 2006).

Literature References
PubMed ID Title Journal Year
7935840 Krox-20 controls myelination in the peripheral nervous system

Babinet, C, Chennoufi, AB, Levi, G, Seitanidou, T, Schneider-Maunoury, S, Charnay, P, Topilko, P, Baron-Van Evercooren, A

Nature 1994
10727776 Myelin synthesis in the peripheral nervous system

Cassagne, C, Sargueil, F, Heape, AM, Garbay, B

Prog. Neurobiol. 2000
18634568 Interactions of Sox10 and Egr2 in myelin gene regulation

Nagarajan, R, Jones, EA, Mager, GM, Ward, RM, Chang, LW, Svaren, J, Jang, SW, Srinivasan, R, Gokey, NG

Neuron Glia Biol. 2007
15695336 Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination

Nagarajan, R, Wang, JY, Araki, T, Le, N, Milbrandt, J, Schmidt, RE

Proc. Natl. Acad. Sci. U.S.A. 2005
16923174 In vivo detection of Egr2 binding to target genes during peripheral nerve myelination

Wrabetz, L, Svaren, J, Leblanc, SE, Jang, SW, Roopra, A

J. Neurochem. 2006
16319321 Functional organization of a Schwann cell enhancer

Friedman, HC, Forghani, R, Hudson, TJ, Dib, S, Peterson, A, Drouin, R, Lepage, P, Denarier, E, Dionne, N, Farhadi, HF

J. Neurosci. 2005
11356866 A distal upstream enhancer from the myelin basic protein gene regulates expression in myelin-forming schwann cells

Forghani, R, Hudson, TJ, Tretjakoff, I, Peterson, A, Lepage, P, Garofalo, L, Valera, P, Foran, DR, Farhadi, HF

J. Neurosci. 2001
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MBP gene:EGR2:SOX10 [nucleoplasm] (Homo sapiens)
Active Unit
EGR2 [nucleoplasm]
SOX10 [nucleoplasm]
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-07-27)
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