Reactome | MBP gene expression

MBP gene expression

Stable Identifier

R-HSA-9614773

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

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Myelin basic protein (MBP) is a key component of the myelin sheath synthesized by Schwan cells in the peripheral nervous system (Garbay et al, 2000). MBP expression is regulated by EGR2, which binds to both to an upstream enhancer and to sites within the first intron of the MBP gene (Forgahni et al, 2001; Denarier et al, 2005; Jang et al, 2006). Consistent with this, MBP expression is decreased in EGR2 knockout mice (Topilko et al, 1994, Le et al, 2005). Sequence analysis suggests that, as is the case for MPZ, SOX10 may act in conjunction with EGR2 to regulate MBP expression (Jones et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
10727776	Myelin synthesis in the peripheral nervous system Garbay, B, Heape, AM, Sargueil, F, Cassagne, C	Prog. Neurobiol.	2000
7935840	Krox-20 controls myelination in the peripheral nervous system Topilko, P, Schneider-Maunoury, S, Levi, G, Baron-Van Evercooren, A, Chennoufi, AB, Seitanidou, T, Babinet, C, Charnay, P	Nature	1994
18634568	Interactions of Sox10 and Egr2 in myelin gene regulation Jones, EA, Jang, SW, Mager, GM, Chang, LW, Srinivasan, R, Gokey, NG, Ward, RM, Nagarajan, R, Svaren, J	Neuron Glia Biol.	2007
15695336	Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination Le, N, Nagarajan, R, Wang, JY, Araki, T, Schmidt, RE, Milbrandt, J	Proc. Natl. Acad. Sci. U.S.A.	2005
16923174	In vivo detection of Egr2 binding to target genes during peripheral nerve myelination Jang, SW, Leblanc, SE, Roopra, A, Wrabetz, L, Svaren, J	J. Neurochem.	2006
16319321	Functional organization of a Schwann cell enhancer Denarier, E, Forghani, R, Farhadi, HF, Dib, S, Dionne, N, Friedman, HC, Lepage, P, Hudson, TJ, Drouin, R, Peterson, A	J. Neurosci.	2005
11356866	A distal upstream enhancer from the myelin basic protein gene regulates expression in myelin-forming schwann cells Forghani, R, Garofalo, L, Foran, DR, Farhadi, HF, Lepage, P, Hudson, TJ, Tretjakoff, I, Valera, P, Peterson, A	J. Neurosci.	2001