FOXO1,FOXO3,(FOXO4) bind FASLG gene promoter

Stable Identifier
Reaction [binding]
Homo sapiens
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Unphosphorylated FOXO1 (Ciechomska et al. 2003) and FOXO3 (Brunet et al. 1999), and possibly FOXO4, can bind to three Forkhead-responsive elements in the promoter of the FASLG gene. The FASLG gene encodes FAS ligand (also known as TNFSF6 or CD95-L), a cytokine that binds the FAS receptor (TNFRSF6) and triggers extrinsic apoptosis pathway. AKT-mediated phosphorylation of FOXO3 prevents binding of FOXO3 to the FASLG promoter (Brunet et al. 1999).

Literature References
PubMed ID Title Journal Year
14576824 Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells

Ciechomska, I, Pyrzynska, B, Kazmierczak, P, Kaminska, B

Oncogene 2003
10102273 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Brunet, A, Bonni, A, Zigmond, MJ, Lin, MZ, Juo, P, Hu, LS, Anderson, MJ, Arden, KC, Blenis, J, Greenberg, ME

Cell 1999
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